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Technical Data
| Formula | C27H29ClN6O2 |
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| Molecular Weight | 505.01 | CAS No. | 288250-47-5 | |
| Solubility (25°C)* | In vitro | DMSO | 11 mg/mL (21.78 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Y-320 is an orally active immunomodulator, and inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM. |
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| In vitro | Y-320 also inhibits the production of IFN-γ and TNF-α by mouse CD4 T cells stimulated with IL-15, CXCL12, and anti-CD3 mAb. [1] |
| In vivo | Y-320 (0.3-3 mg/kg p.o.) ameliorates collagen-induced arthritis (CIA) in Mice with a reduction of IL-17 mRNA in arthritic joints, and also shows therapeutic effects on CIA in cynomolgus monkeys. Moreover, Y-320 shows a synergistic effect in combination with anti-TNF-α mAb on chronic-progressing CIA in mice. [1] |
Protocol (from reference)
| Animal Study:[1] |
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Selleck's Y-320 has been cited by 4 publications
| Porcine Reproductive and Respiratory Syndrome Virus Adapts Antiviral Innate Immunity via Manipulating MALT1 [ mBio, 2022, e0066422] | PubMed: 35467421 |
| PRRSV Nsp11 Antagonizes Broad Antiviral Effects of MCPIP1 via Inducing IL-17 Expression [ J Virol, 2021, JVI0111921] | PubMed: 34468170 |
| Blockage of IL-17 Ameliorates Aβ-Induced Neurotoxicity and Cognitive Decline [ Research Square, 2021, 10.21203/rs.3.rs-742937/v1] | PubMed: None |
| IL-17 Promotes Scar Formation by Inducing Macrophage Infiltration. [ Am J Pathol, 2018, 188(7):1693-1702] | PubMed: 29753790 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.