Xylitol

Catalog No.S4546 Batch:S454601

Technical Data

Formula	C₅H₁₂O₅
Molecular Weight	152.15	CAS No.	87-99-0
Solubility (25°C)*	In vitro	DMSO	30 mg/mL (197.17 mM)
		Water	30 mg/mL (197.17 mM)
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description

Xylitol (Adonitol, Ribitol, Xylite, D-Xylitol, Adonite) is a sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener.

Targets

angiogenesis ^[1]

In vitro

Xylitol is reported to have an inhibitory effect on LPS-induced inflammatory cytokine expression^[2]. Xylitol strongly inhibits tube formation, migration, and invasion of HUVECs. Xylitol decreases the mRNA expression of key angiogenic molecules and their receptors (VEGF, KDR, bFGF and bFGFR-II) in a dose-dependent manner. Also, it suppresses NF-κB and Akt activation of HUVECs^[1].

In vivo

Xylitol triggers the release of insulin in dogs^[3] and inhibits in vivo angiogenesis. It prominently inhibits the formation of neo-microvessels in the Matrigel assay, and reduces the hemoglobin content in the Matrigel plug^[1].

Protocol (from reference)

Cell Assay:^{^[1]}	Cell lines human umbilical vein endothelial cells（HUVECs） Concentrations 0.1, 0.3, 0.5 and 1 mM Incubation Time 18 h Method In vitro tube formation assay：HUVECs (2×10⁴ cells) are seeded on a layer of previously polymerized Matrigel and treated with or without xylitol. Matrigel culture is incubated at 37°C. After 6 h, changes in cell morphology are captured through a phase contrast microscope and photographed at ×40 magnification. Each sample is assayed in duplicate and independent experiments are repeated three times.
Animal Study:^{^[1]}	Animal Models Specific pathogen-free (SPF) male C57BL/6 mice Dosages 0.1 or 1 mM Administration s.c.

Cell Assay:^{^[1]}

Cell lines
human umbilical vein endothelial cells（HUVECs）
Concentrations
0.1, 0.3, 0.5 and 1 mM
Incubation Time
18 h
Method
In vitro tube formation assay：HUVECs (2×10⁴ cells) are seeded on a layer of previously polymerized Matrigel and treated with or without xylitol. Matrigel culture is incubated at 37°C. After 6 h, changes in cell morphology are captured through a phase contrast microscope and photographed at ×40 magnification. Each sample is assayed in duplicate and independent experiments are repeated three times.

Animal Study:^{^[1]}

Animal Models
Specific pathogen-free (SPF) male C57BL/6 mice
Dosages
0.1 or 1 mM
Administration
s.c.

References

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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