Tezacaftor (VX-661)

Catalog No.S7059 Batch:S705901

Print

Technical Data

Formula

C26H27F3N2O6
Molecular Weight 520.5 CAS No. 1152311-62-0
Solubility (25°C)* In vitro DMSO 104 mg/mL (199.8 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Tezacaftor (VX-661) is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface. Phase 2.
Targets
F508del-CFTR [1]
(Cell-free assay)
In vitro

VX-661, known as a CTFR corrector, allows F508del mutant channels to escape degradation and transit to the cell membrane.

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    Primary HBE cells

  • Concentrations

    5 μM

  • Incubation Time

    24 h

  • Method

    Cells were treated with indicated concentration of drug for 24 h.
Animal Study:

[3]
  • Animal Models

    Male FVB/n mice

  • Dosages

    2 mg/kg

  • Administration

    i.p.

Customer Product Validation

Data from [Data independently produced by Sci Transl Med, 2014, 6(246), 246ra96]

Data from [Data independently produced by , , J Cyst Fibros, 2018, doi:10.1016/j.jcf.2018.07.001]

Data from [Data independently produced by , , NPJ Genom Med. 2017, 2:12]

Selleck's Tezacaftor (VX-661) has been cited by 130 publications

Endometrium-derived organoids from cystic fibrosis patients and mice as new models to study disease-associated endometrial pathobiology [ Cell Mol Life Sci, 2025, 82(1):109] PubMed: 40074868
Inflammation-induced loss of CFTR-expressing airway ionocytes in non-eosinophilic asthma [ Respirology, 2025, 30(1):25-40] PubMed: 39358991
Human Induced Lung Organoids: A Promising Tool for Cystic Fibrosis Drug Screening [ Int J Mol Sci, 2025, 26(2)437] PubMed: 39859153
Inhibitors of the ubiquitin‑proteasome system rescue cellular levels and ion transport function of pathogenic pendrin (SLC26A4) protein variants [ Int J Mol Med, 2025, 55(5)69] PubMed: 40052591
Evaluation of the response to elexacaftor-tezacaftor-ivacaftor of the rare CFTR variants L383S, I507del, L1065P and R1066H in intestinal organoid-derived epithelial monolayers [ J Cyst Fibros, 2025, S1569-1993(25)00059-1] PubMed: 39979195
Septin-dependent defense mechanisms against Pseudomonas aeruginosa are stalled in cystic fibrosis bronchial epithelial cells [ Eur J Cell Biol, 2024, 103(2):151416] PubMed: 38636185
Ligand-based virtual-screening identified a novel CFTR ligand which improves the defective cell surface expression of misfolded ABC transporters [ Front Pharmacol, 2024, 15:1370676] PubMed: 38666024
Comprehensive Assessment of CFTR Modulators' Therapeutic Efficiency for N1303K Variant [ Int J Mol Sci, 2024, 25(5)2770] PubMed: 38474016
Estimation of Chloride Channel Residual Function and Assessment of Targeted Drugs Efficiency in the Presence of a Complex Allele [L467F;F508del] in the CFTR Gene [ Int J Mol Sci, 2024, 25(19)10424] PubMed: 39408749
The F508del-CFTR trafficking correctors elexacaftor and tezacaftor are CFTR-independent Ca2+-mobilizing agonists normalizing abnormal Ca2+ levels in human airway epithelial cells [ Respir Res, 2024, 25(1):436] PubMed: 39702307

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.