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Technical Data
| Formula | C45H54N4O8.2C4H6O6 |
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| Molecular Weight | 1079.11 | CAS No. | 125317-39-7 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (92.66 mM) | |
| Water | 100 mg/mL (92.66 mM) | |||
| Ethanol | 100 mg/mL (92.66 mM) | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Vinorelbine ditartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. Vinorelbine Tartrate exhibits anti-tumor activities via inducing the mitotic apoptosis, autophagy and inflammation. | |
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| In vitro | Vinorelbine inhibits microtubule assembly by inducing tubulin aggregation into spirals and paracrystals. [1] Vinorelbine shows potent antiproliferative activity against a series of tumor cells, including human melanoma, non-small-cell lung cancer, breast cancer, etc. [2][3][4] |
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| In vivo | In vivo, Vinorelbine also shows antitumour activity against a series of subcutaneously-implanted human tumour xenografts. [5] |
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| Features | A semi-synthetic vinca alkaloid as an anti-mitotic chemotherapy drug. |
Protocol (from reference)
| Animal Study: |
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References
Customer Product Validation
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, , Cynthia Bernia from McGill University
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Data from [Data independently produced by , , Mol Cancer Ther, 2016, 15(8):1823-33.]
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Data from [Data independently produced by , , J Biol Chem, 2017, 292(19):7806-7816]
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Data from [Data independently produced by , , Breast Cancer Res Treat, 2018, 172(1):23-32]
Selleck's Vinorelbine ditartrate has been cited by 44 publications
| Targeting of mutant-p53 and MYC as a novel strategy to inhibit oncogenic SPAG5 activity in triple negative breast cancer [ Cell Death Dis, 2024, 15(8):603] | PubMed: 39164278 |
| Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment [ BMC Pharmacol Toxicol, 2024, 25(1):25] | PubMed: 38444002 |
| Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment [ BMC Pharmacol Toxicol, 2024, 25(1):25] | PubMed: 38444002 |
| Targeting MCL-1 triggers DNA damage and an anti-proliferative response independent from apoptosis induction [ Cell Rep, 2023, 42(10):113176] | PubMed: 37773750 |
| Comprehensive molecular characterization of adenoid cystic carcinoma reveals tumor suppressors as novel drivers and prognostic biomarkers [ J Pathol, 2023, 261(3):256-268] | PubMed: 37565350 |
| Small extracellular vesicles promote invadopodia activity in glioblastoma cells in a therapy-dependent manner [ Cell Oncol (Dordr), 2023, 10.1007/s13402-023-00786-w] | PubMed: 37014551 |
| Assessment of stromal SCD-induced drug resistance of PDAC using 3D-printed zPDX model chips [ iScience, 2023, 26(1):105723] | PubMed: 36590169 |
| Immunofluorescence-Based Assay for High-Throughput Analysis of Multidrug Resistance Markers in Non-Small Cell Lung Carcinoma Patient-Derived Cells [ Diagnostics (Basel), 2023, 13(24)3617] | PubMed: 38132201 |
| Immune checkpoint inhibitors modulate the cytotoxic effect of chemotherapy in lung adenocarcinoma cells [ Oncol Lett, 2023, 25(4):152] | PubMed: 36936028 |
| Immune checkpoint inhibitors modulate the cytotoxic effect of chemotherapy in lung adenocarcinoma cells [ Oncology Letters, 2023, 152] | PubMed: None |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.