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Technical Data
| Formula | C17H18ClN3O |
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| Molecular Weight | 315.80 | CAS No. | 917369-31-4 | |
| Solubility (25°C)* | In vitro | DMSO | 56 mg/mL (177.32 mM) | |
| Water | 56 mg/mL (177.32 mM) | |||
| Ethanol | 56 mg/mL (177.32 mM) | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Verubulin hydrochloride(MPC 6827 hydrochloride) is a microtubule destabilizer and vascular disrupting agent that achieve high brain concentration relative to plasma in animals. |
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| In vitro | Verubulin hydrochloride is the hydrochloride of compound Verubulin. Verubulin(MPC-6827) is a potent inhibitors of cancer cell growth, with GI50 values of 3-6 nM in T47D, HCT116 and SNU-398 cells.[2] |
| In vivo | Verubulin(MPC-6827) has excellent blood brain barrier penetration, and is highly efficacious in a MX-1 breast tumor model. [2] |
Protocol (from reference)
References
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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