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Formula | C27H39NO2 |
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Molecular Weight | 409.60 | CAS No. | 60-70-8 | |
Solubility (25°C)* | In vitro | DMSO | 63 mg/mL (153.8 mM) | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Veratramine (NSC 17821, NSC 23880), a major alkaloid from Veratrum nigrum L., has distinct anti-tumor and anti-hypertension effects. It is a good membrane permeant, undergoes rapid passive diffusion, and has a good stability in the gastrointestinal tract during its absorption. |
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In vitro | Veratramine antagonizes the Na+ channel-gating mechanism of ceveratrum alkaloids by blocking Na+ channels. Veratramine also shows serotonin (5-HT) agonist activity, acting on presynaptic 5-HT neurons[1]. |
In vivo | The administration of vertatramine induces generalized tremors, myoclonus, hindlimb abduction, backward gait, and Straub tail, similar to the 5-HT syndrome in mice. Veratramine causes bradycardia and periodic rhythm in the sinoatrial node of the guinea pig. The lethal dose 50% (LD50) of VAM for mice is 15.9 mg/kg with intragastrical administration [1]. Vertatramine causes DNA damage in the cerebellum and cerebral cortex of mice in a dose-dependent manner. As a major Veratrum alkaloid, veratramine (VAM) is significantly effective against hypertension by reflective inhibition of vasomotor center and tumor as an antagonist of the hedgehog signaling. Vertatramine may exert neurotoxic effects[2]. |
Animal Study:[1] |
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