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Technical Data
| Formula | C27H38N2O4.HCl |
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| Molecular Weight | 491.06 | CAS No. | 152-11-4 | |
| Solubility (25°C)* | In vitro | DMSO | 98 mg/mL (199.56 mM) | |
| Water | 98 mg/mL (199.56 mM) | |||
| Ethanol | 98 mg/mL (199.56 mM) | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4. | |
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| In vitro | The enzyme hydrolase activity of recombinant CES2 is substantially inhibited by diltiazem and verapamil (Ki = 0.25 ± 0.02 and 3.84 ± 0.99μM, respectively). |
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| In vivo | Verapamil confers an anti-arrhythmic effect via calcium influx inhibition, inhibition of oxygen consumption and accompanied by preservation of Cx43 protein in rat heart. |
Protocol (from reference)
References
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Customer Product Validation
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Data from [Data independently produced by , , Front Pharmacol, 2018, 9:1298]
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Data from [Data independently produced by , , BMC Cancer, 2015, 15:553.]
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Data from [Data independently produced by , , Exp Hematol, 2017, 2.436]
Selleck's Verapamil HCl has been cited by 24 publications
| A new TROP2-targeting antibody-drug conjugate shows potent antitumor efficacy in breast and lung cancers [ NPJ Precis Oncol, 2024, 8(1):94] | PubMed: 38654141 |
| Coumarins with Different Substituents from Leonurus japonicus Have Opposite Effects on Uterine Smooth Muscle [ Int J Mol Sci, 2024, 25(18)10162] | PubMed: 39337649 |
| Verapamil Attenuates the Severity of Tendinopathy by Mitigating Mitochondrial Dysfunction through the Activation of the Nrf2/HO-1 Pathway [ Biomedicines, 2024, 12(4)904] | PubMed: 38672259 |
| Establishment and Molecular Characterization of an In Vitro Model for PARPi-Resistant Ovarian Cancer [ Cancers (Basel), 2023, 15(15)3774] | PubMed: 37568590 |
| Inhibition of NPC1L1 disrupts adaptive responses of drug-tolerant persister cells to chemotherapy [ EMBO Mol Med, 2022, 14(2):e14903] | PubMed: 35023619 |
| Moderate heart rate reduction promotes cardiac regeneration through stimulation of the metabolic pattern switch [ Cell Rep, 2022, 38(10):110468] | PubMed: 35263588 |
| Apoptotic Extracellular Vesicles Ameliorate Multiple Myeloma by Restoring Fas-Mediated Apoptosis [ ACS Nano, 2021, 10.1021/acsnano.1c03517] | PubMed: 34506129 |
| Discovery of new pyrimidopyrrolizine/indolizine-based derivatives as P-glycoprotein inhibitors: Design, synthesis, cytotoxicity, and MDR reversal activities [ Eur J Med Chem, 2021, 218:113403] | PubMed: 33823396 |
| Low doses of BPF-induced hypertrophy in cardiomyocytes derived from human embryonic stem cells via disrupting the mitochondrial fission upon the interaction between ERβ and calcineurin A-DRP1 signaling pathway [ Cell Biol Toxicol, 2021, 10.1007/s10565-021-09615-y] | PubMed: 34023961 |
| QTMP, a Novel Thiourea Polymer, Causes DNA Damage to Exert Anticancer Activity and Overcome Multidrug Resistance in Colorectal Cancer Cells [ Front Oncol, 2021, 11:667689] | PubMed: 34123833 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.