VB124

Catalog No.S9929 Batch:S992901

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Technical Data

Formula

C23H23ClN2O4
Molecular Weight 426.89 CAS No. 2230186-18-0
Solubility (25°C)* In vitro DMSO 85 mg/mL (199.11 mM)
Ethanol 85 mg/mL (199.11 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5%DMSO Corn oil
5.0mg/ml Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description VB124, a potent and selective MCT4 inhibitor, specifically inhibits lactate efflux/import in MDA-MB-231 cells expressing MCT4, and is used for the research of cardiac hypertrophy, heart failure, and metabolism. 
Targets
MCT4 [1]
(in the MCT4 fluorescence-based activity assays)		 MCT4 [1]
(in the MCT4 fluorescence-based activity assays)
8.6 nM 19 nM
In vitro

VB124 is a potent and selective MCT4 inhibitor that specifically inhibits lactate efflux and redirects glycolytic carbon flux into mitochondrial pyruvate oxidation.

Protocol (from reference)

Animal Study:

[2]
  • Animal Models

    C57BL/6 mice

  • Dosages

    30 mg/kg

  • Administration

    o.g.

Selleck's VB124 has been cited by 2 publications

MCT4-dependent lactate transport: a novel mechanism for cardiac energy metabolism injury and inflammation in type 2 diabetes mellitus [ Cardiovasc Diabetol, 2024, 23(1):96] PubMed: 38486199
Functional heterogeneity of MCT1 and MCT4 in metabolic reprogramming affects osteosarcoma growth and metastasis [ J Orthop Surg Res, 2023, 18(1):131] PubMed: 36814318

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.