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Technical Data
| Formula | C26H34ClN3O4
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| Molecular Weight | 488.02 | CAS No. | 1809336-39-7 | |
| Solubility (25°C)* | In vitro | DMSO | 98 mg/mL (200.81 mM) | |
| Ethanol | 98 mg/mL (200.81 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Valemetostat (DS-3201, DS-3201b) is a selective EZH1/2 dual inhibitor. | ||
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| In vitro | Valemetostat significantly reducs ATL cell viability compared with the others. Valemetostat significantly reactivates the expression of the highly H3K27me3-accumulated EZH1/2 target genes in an ex vivo culture of primary ATL cells. Valemetostat shows superior anti-growth effects compared with EZH2-selective inhibitor in malignant lymphoma cell lines.[1]. |
Protocol (from reference)
References
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Selleck's Valemetostat (DS-3201) has been cited by 7 publications
| Lineage-specific canonical and non-canonical activity of EZH2 in advanced prostate cancer subtypes [ Nat Commun, 2024, 15(1):6779] | PubMed: 39117665 |
| Inhibiting EZH2 targets atypical teratoid rhabdoid tumor by triggering viral mimicry via both RNA and DNA sensing pathways [ Nat Commun, 2024, 15(1):9321] | PubMed: 39472584 |
| A novel EZH1/2 dual inhibitor inhibits GCB DLBCL through cell cycle regulation and M2 tumor-associated macrophage polarization [ J Biol Chem, 2024, 300(11):107788] | PubMed: 39303914 |
| Cytotoxicity of bendamustine, alone and in combination with novel agents, toward adult T-cell leukemia cells [ PLoS One, 2024, 19(9):e0309533] | PubMed: 39348376 |
| 5-AZA Upregulates SOCS3 and PTPN6/SHP1, Inhibiting STAT3 and Potentiating the Effects of AG490 against Primary Effusion Lymphoma Cells [ Curr Issues Mol Biol, 2024, 46(3):2468-2479] | PubMed: 38534772 |
| Epigenetic plasticity safeguards heterochromatin configuration in mammals [ Nucleic Acids Res, 2023, gkad387] | PubMed: 37178005 |
| Exercise-induced histone H3 trimethylation at lysine 27 facilitates the adaptation of skeletal muscle to exercise in mice [ J Physiol, 2022, 600(14):3331-3353] | PubMed: 35666835 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.