Umbelliferone

Catalog No.S3675 Batch:S367501

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Technical Data

Formula

C9H6O3
Molecular Weight 162.14 CAS No. 93-35-6
Solubility (25°C)* In vitro DMSO 32 mg/mL (197.36 mM)
Ethanol 32 mg/mL (197.36 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Umbelliferone (7-hydroxycoumarin, hydrangine, skimmetine, beta-umbelliferone) is a 7-hydroxycoumarin that is a pharmacologically active agent. It is a fluorescing compound used as a sunscreen agent and shows good inhibitions of DPPH, hydroxyl, superoxide anion and ABTS radicals with anti-inflammatory, anti-hyperglycaemic, molluscicidal and anti-tumor activities.
In vitro Treatment of KB cells with Umbelliferone (UMB), prevents and reduces the cell proliferation with the IC50--200 μM as well as induces loss of cell viability, morphology change and internucleosomal DNA fragmentation in a concentration dependent manner. UMB induces apoptosis in KB cells in a dose dependent manner. UMB has the potential to increase oxidative DNA damage in KB cells through DNA tail formation significantly. UMB brings a dose-dependent elevation of reactive oxygen species (ROS), which is evidenced by the DCF fluorescence, alters the mitochondrial membrane potential in KB cells. UMB exhibits anticancer effect on KB cell line with the increased generation of intracellular ROS, triggers oxidative stress mediated depolarization of mitochondria, which contributes cell death via DNA damage as well as cell cycle arrest at G0/G1 phase. UMB protects alcoholic fatty liver, detoxify reactive aldehyde, radiation mediated cellular damage in human blood lymphocytes, immuno modulators and treat vascular lesions[1].
In vivo Treatment with umbelliferone (60 and 90 mg/kg) causes a marked reduction of cellularity and eosinophil numbers in bronchoalveolar lavage fluids from asthmatic mice. In addition, a decrease in mucus production and lung inflammation are observed in mice treated with umbelliferone. A reduction of IL-4, IL-5, and IL-13, but not of IFN-γ, is found in bronchoalveolar lavage fluids of mice treated with umbelliferone. umbelliferone attenuates airway inflammation in a murine model of asthma[2]. Dietary administration of umbelliferone and esculetin significantly attenuates MPTP-induced neurotoxicity in the substantia nigra pars compacta but not striatum, as measured by tyrosine hydroxylase staining. Umbelliferone also prevents MPTP-dependent caspase 3 activation, an indicator of apoptosis, but does not inhibit monoamine oxidase activity[3].

Protocol (from reference)

Cell Assay:[1]
  • Cell lines

    KB cells

  • Concentrations

    0–500 μg/ml

  • Incubation Time

    24 h

  • Method

    Cells are seeded in 6 or 12 well plates prior to the addition of UMB. The KB cells are incubates with UMB (0-500 μg/ml of KB cells) for 24 h.
Animal Study:[2]
  • Animal Models

    BALB/c mice

  • Dosages

    30, 60 and 90 mg/kg

  • Administration

    oral

Selleck's Umbelliferone has been cited by 1 publication

Umbelliferone delays the progression of diabetic nephropathy by inhibiting ferroptosis through activation of the Nrf-2/HO-1 pathway [ Food Chem Toxicol, 2022, S0278-6915(22)00089-8] PubMed: 35278496

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.