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Technical Data
| Formula | C22H16F4N4OS |
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| Molecular Weight | 460.45 | CAS No. | 2443816-45-1 | |
| Solubility (25°C)* | In vitro | DMSO | 92 mg/mL (199.8 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively. | ||||
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| In vitro | ULK-101 suppresses autophagy induction and autophagic flux in response to different stimuli. ULK-101 sensitizes KRAS mutant lung cancer cells to nutrient stress[1]. |
Protocol (from reference)
| Cell Assay: |
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Selleck's ULK-101 has been cited by 14 publications
| Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks [ Immunity, 2024, 57(2):287-302.e12] | PubMed: 38354704 |
| Chronic hypoxia stabilizes 3βHSD1 via autophagy suppression [ Cell Rep, 2024, 43(1):113575] | PubMed: 38181788 |
| Targeting autophagy as a therapeutic strategy in pediatric acute lymphoblastic leukemia [ Sci Rep, 2024, 14(1):4000] | PubMed: 38369625 |
| Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response [ EMBO J, 2023, e113349.] | PubMed: 37306101 |
| Spatially resolved phosphoproteomics reveals fibroblast growth factor receptor recycling-driven regulation of autophagy and survival [ Nat Commun, 2022, 13(1):6589] | PubMed: 36329028 |
| Inhibition of AKT induces p53/SIRT6/PARP1-dependent parthanatos to suppress tumor growth [ Cell Commun Signal, 2022, 20(1):93] | PubMed: 35715817 |
| Autophagy regulates transforming growth factor β signaling and receptor trafficking [ Biochim Biophys Acta Mol Cell Res, 2022, S0167-4889(22)00076-3] | PubMed: 35605790 |
| Regulation of IFNα-induced expression of the short ACE2 isoform by ULK1 [ Mol Immunol, 2022, 147:1-9] | PubMed: 35489289 |
| TP53 loss-of-function causes vulnerability to autophagy inhibition in aggressive prostate cancer [ Int J Urol, 2022, 29(9):1085-1094] | PubMed: 35975690 |
| Synergetic contributions of viral VP1, VP3, and 3C to activation of the AKT-AMPK-MAPK-MTOR signaling pathway for Seneca Valley virus-induced autophagy [ J Virol, 2021, JVI0155021] | PubMed: 34757844 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.