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Formula | C24H28O2 |
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Molecular Weight | 348.48 | CAS No. | 71441-28-6 | |
Solubility (25°C)* | In vitro | DMSO | 15 mg/mL (43.04 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | TTNPB is a potent RAR agonist, and inhibits binding of [3H]tRA with IC50 of 5.1 nM, 4.5 nM, and 9.3 nM for human RARα, β, and γ, respectively. | ||||||
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Targets |
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In vitro | TTNPB binds to nuclear retinoic acid receptors with high affinity, inhibits binding of [3H]tRA with IC50 of 3.8 nM, 4.0 nM, and 4.5 nM for mRARα, β, and γ, respectively. [1] TTNPB increases transcriptional activation of Mouse RARs in JEG-3 cells after 72 h using conditioned media with EC50 of 2.0 nM, 1.1 nM and 0.8 nM for mRARα, β, and γ, respectively. [2] TTNPB inhibits the growth of normal human mammary epithelial cells (HMECs) and estrogen receptor-positive (ER-positive) breast cancer cells by inducing G1 cell cycle blockade. [3] TTNPB causes a concentration-dependent decrease in ES-D3 cell differentiation. [4] | ||||||
In vivo | TTNPB (0.25 mg/kg) causes growth inhibition in both MXT-HS and MXT-HI models by inducing cell apoptosis. [5] |
Kinase Assay:[1] |
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Cell Assay:[3] |
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Animal Study:[5] |
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A noncoding variant confers pancreatic differentiation defect and contributes to diabetes susceptibility by recruiting RXRA [ Nat Commun, 2024, 15(1):9771] | PubMed: 39532884 |
Prostatic lineage differentiation from human embryonic stem cells through inducible expression of NKX3-1 [ Stem Cell Res Ther, 2024, 15(1):274] | PubMed: 39218930 |
Intrafollicular Retinoic Acid Signaling Is Important for Luteinizing Hormone-Induced Oocyte Meiotic Resumption [ Genes (Basel), 2023, 14(4)946] | PubMed: 37107703 |
Induction of mouse totipotent stem cells by a defined chemical cocktail [ Nature, 2022, 10.1038/s41586-022-04967-9] | PubMed: 35728625 |
Generation of mitochondria-rich kidney organoids from expandable intermediate mesoderm progenitors reprogrammed from human urine cells under defined medium [ Cell Biosci, 2022, 12(1):174] | PubMed: 36243732 |
Direct Reprograming of Mouse Fibroblasts into Dermal Papilla Cells via Small Molecules [ Int J Mol Sci, 2022, 23(8)4213] | PubMed: 35457029 |
ATRA-mediated-crosstalk between stellate cells and Kupffer cells inhibits autophagy and promotes NLRP3 activation in acute liver injury [ Cell Signal, 2022, 93:110304] | PubMed: 35278669 |
Identification of hepatic fibrosis inhibitors through morphometry analysis of a hepatic multicellular spheroids model [ Sci Rep, 2021, 11(1):10931] | PubMed: 34035369 |
GATA6-AS1 Regulates GATA6 Expression to Modulate Human Endoderm Differentiation [ Stem Cell Reports, 2020, S2213-6711(20)30291-5] | PubMed: 32795420 |
Bmi1 inhibitor PTC-209 promotes Chemically-induced Direct Cardiac Reprogramming of cardiac fibroblasts into cardiomyocytes. [ Sci Rep, 2020, 28;10(1):7129] | PubMed: 32346096 |
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.