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Technical Data
| Formula | C12H14O5 |
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| Molecular Weight | 238.24 | CAS No. | 90-50-6 | |
| Solubility (25°C)* | In vitro | DMSO | 47 mg/mL (197.28 mM) | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | 3,4,5-Trimethoxycinnamic acid (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA/BZ receptor complex. | |
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| In vivo | TMCA decreased the locomotor activity in mice, prolonged total sleep time, and reduced sleep latency induced by pentobarbital. TMCA also increased the total sleep time and non-rapid eye movement (NREM) sleep. It alters sleep architecture through GABAAergic systyems[1]. TMCA exhibits anti-stress actions by the suppression of norepinephrine (NE) content in locus coeruleus (LC) induced by corticotrophin-releasing hormone (CRH)[2]. |
Protocol (from reference)
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References
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RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.