Trimetazidine dihydrochloride

Catalog No.S4543 Batch:S454301

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Technical Data

Formula

C14H22N2O3.2HCl
Molecular Weight 339.26 CAS No. 13171-25-0
Solubility (25°C)* In vitro DMSO 67 mg/mL (197.48 mM)
Water 67 mg/mL (197.48 mM)
Ethanol 67 mg/mL (197.48 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Trimetazidine dihydrochloride (Yoshimilon, Kyurinett, Vastarel F) is a kind of drug for treatment of chronic ischemic disorders. It improves myocardial glucose utilization through inhibition of fatty acid metabolism, known as fatty acid oxidation inhibitor.
Targets
mitochondrial long-chain 3-ketoacyl thiolase [1]
(Cell-free assay)
75 nM
In vitro Trimetazidine up-regulates miR-21 expression, then miR-21 targets PTEN increasing the PI3K pathway and finally the activation of this pathway counteracts the apoptotic effect of hypoxia/reperfusion[3].
In vivo The administration of TMZ reduces myocardial infarction size in WT C57BL/6J hearts. Both AMPK and ERK signaling pathways mediate the cardioprotection of TMZ against ischemic injury. Trimetazidine Shifts Metabolism from Fatty Acid Oxidation to Glucose Oxidation and improves Contractile Functions of Cardiomyocytes during Hypoxia[2].

Protocol (from reference)

Cell Assay:

[3]
  • Cell lines

    human H9C2 cell line

  • Concentrations

    10 μM

  • Incubation Time

    48 h

  • Method

    The H9C2 cells are randomly assigned into three groups: Sham group, in which the cells are treated with 0μM TMZ for 48 h and then cultured under normal oxygenation conditions (5% CO2, and 95% air); H/R group, in which cells are treated with 0 μM TMZ for 48 h and then cultured under H/R conditions; and H/R+TMZ group, in which cells are treated with 10 μM TMZ for 48 h and then subjected to H/R treatment.
Animal Study:

[2]
  • Animal Models

    C57BL/6J, AMPK KD mice

  • Dosages

    0.5 mg/kg

  • Administration

    tail vein injection

Selleck's Trimetazidine dihydrochloride has been cited by 8 publications

Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma [ J Immunother Cancer, 2024, 12(11)e009805] PubMed: 39581704
Mindin Activates Autophagy for Lipid Utilization and Facilitates White Spot Syndrome Virus Infection in Shrimp [ mBio, 2023, e0291922.] PubMed: 36779788
Repurposing of Trimetazidine for amyotrophic lateral sclerosis: A study in SOD1G93A mice [ Br J Pharmacol, 2022, 179(8):1732-1752] PubMed: 34783031
Repurposing of Trimetazidine for amyotrophic lateral sclerosis: A study in SOD1G93A mice [ Br J Pharmacol, 2022, 179(8):1732-1752] PubMed: 34783031
Trimetazidine affects pyroptosis by targeting GSDMD in myocardial ischemia/reperfusion injury [ Inflamm Res, 2022, 10.1007/s00011-021-01530-6] PubMed: 34993560
QiShenYiQi Pill Ameliorates Cardiac Fibrosis After Pressure Overload-Induced Cardiac Hypertrophy by Regulating FHL2 and the Macrophage RP S19/TGF-β1 Signaling Pathway [ Front Pharmacol, 2022, 13:918335] PubMed: 35910357
QiShenYiQi Pill Ameliorates Cardiac Fibrosis After Pressure Overload-Induced Cardiac Hypertrophy by Regulating FHL2 and the Macrophage RP S19/TGF-β1 Signaling Pathway [ Front Pharmacol, 2022, 13:918335] PubMed: 35910357
The role of PAK1 in the sensitivity of kidney epithelial cells to ischemia-like conditions. [ Cell Cycle, 2019, 18(5):596-604] PubMed: 30724698

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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