Tranylcypromine HCl

Catalog No.S4246 Batch:S424607

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Technical Data

Formula

C9H12ClN
Molecular Weight 169.65 CAS No. 1986-47-6
Solubility (25°C)* In vitro DMSO 34 mg/mL (200.41 mM)
Water 34 mg/mL (200.41 mM)
Ethanol 34 mg/mL (200.41 mM)
In vivo (Add solvents to the product individually and in order)
Clear solution
5% DMSO 95% Corn oil
0.425mg/ml Taking the 1 mL working solution as an example, add 50 μL of 8.5 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
1.7mg/ml Taking the 1 mL working solution as an example, add 50 μL of 34 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Tranylcypromine HCl is a monoamine oxidase inhibitor, which inhibits CYP2A6 with Ki of 0.08 μM and 0.2 μM in cDNA-expressing microsomes and Human Liver Microsomes, respectively.
Targets
MAO-B [5]
(Cell-free assay)		 MAO-A [1]
(Cell-free assay)		 LSD1 [5]
(Cell-free assay)
7 μM 11.5 μM 22.3 μM
In vitro R-(+)-Tranylcypromine, (±)-Tranylcypromine, and S-(−)-Tranylcypromine competitively inhibits CYP2A6-mediated metabolism of nicotine with apparent Ki values of 0.05 μM, 0.08 μM, and 2.0 μM, respectively, in human liver microsomes. [1] Tranylcypromine (500 μg/mL) severely inhibits bradykinin-stimulated arachidonic acid release in calf aortic endothelial cells. [2] Tranylcypromine inhibits CYP2A6 and CYP2E1 activity with IC50 of 0.42 μM and 3 μM, respectively, in human liver microsomes. Tranylcypromine induces type II and cyclopropylbenzene type I difference spectrum in human liver microsomes. [3]
In vivo Tranylcypromine injection leads to a large, slow increase in motor activity at 5 mg/kg and 10 mg/kg compared with the saline control in male rats, although 2 mg/kg Tranylcypromine does not induce an increase. Tranylcypromine (10 mg/kg) also causes significant decreases in the number of rearing behaviors in male rats. [4]

Protocol (from reference)

Customer Product Validation

Data from [Data independently produced by , , Front Neurol, 2017, 8:626]

Selleck's Tranylcypromine HCl has been cited by 18 publications

Transcriptome-based chemical screens identify CDK8 as a common barrier in multiple cell reprogramming systems [ Cell Rep, 2023, 42(6):112566] PubMed: 37235474
Kawain Inhibits Urinary Bladder Carcinogenesis through Epigenetic Inhibition of LSD1 and Upregulation of H3K4 Methylation [ Biomolecules, 2023, 13(3)521] PubMed: 36979456
Kawain Inhibits Urinary Bladder Carcinogenesis through Epigenetic Inhibition of LSD1 and Upregulation of H3K4 Methylation [ Biomolecules, 2023, 13(3)521] PubMed: 36979456
Novel dual LSD1/HDAC6 inhibitor for the treatment of cancer [ PLoS One, 2023, 18(1):e0279063] PubMed: 36595522
Novel dual LSD1/HDAC6 inhibitor for the treatment of cancer [ PLoS One, 2023, 18(1):e0279063] PubMed: 36595522
Direct chemical reprogramming of human cord blood erythroblasts to induced megakaryocytes that produce platelets [ Cell Stem Cell, 2022, 29(8):1229-1245.e7] PubMed: 35931032
Direct Reprograming of Mouse Fibroblasts into Dermal Papilla Cells via Small Molecules [ Int J Mol Sci, 2022, 23(8)4213] PubMed: 35457029
Epigenetic Dysregulation Induces Translocation of Histone H3 into Cytoplasm [ Adv Sci (Weinh), 2021, e2100779] PubMed: 34363353
LSD1-mediated demethylation of OCT4 safeguards pluripotent stem cells by maintaining the transcription of PORE-motif-containing genes [ Sci Rep, 2021, 11(1):10285] PubMed: 33986438
Meltome atlas-thermal proteome stability across the tree of life. [ Nat Methods, 2020, 17(5):495-503] PubMed: 32284610

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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