Tiragolumab (anti-TIGIT)

Catalog No.A2028 Batch: A202805

Technical Data

CAS No.	1918185-84-8
Isotype	Human IgG1, κ
Source	CHO cells
Storage (From the date of receipt)	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles.
Purity	99%
Protein concentration	12.27mg/ml
Endotoxin Level	＜1EU/mg

Biological Activity

Description	Tiragolumab (anti-TIGIT) (RG6058, MTIG7192A) is a humanized IgG1/kappa monoclonal antibody that binds TIGIT to prevent its interaction with its ligand PVR (CD155).

References	[1] N. Patil, et al. IMMUNOTHERAPEUTIC APPROACHES\| VOLUME 16, ISSUE 3, SUPPLEMENT , S635-S636, MARCH 01, 2021.

References

[1] N. Patil, et al. IMMUNOTHERAPEUTIC APPROACHES| VOLUME 16, ISSUE 3, SUPPLEMENT , S635-S636, MARCH 01, 2021.

Selleck's Tiragolumab (anti-TIGIT) has been cited by 4 publications

Inhibition of Cbl-b restores effector functions of human intratumoral NK cells [ J Immunother Cancer, 2024, 12(11)e009860]	PubMed: 39551607
The immune checkpoint TIGIT/CD155 promotes the exhaustion of CD8 + T cells in TNBC through glucose metabolic reprogramming mediated by PI3K/AKT/mTOR signaling [ Cell Commun Signal, 2024, 22(1):35]	PubMed: 38216949
Chemotherapy induces myeloid-driven spatial T-cell exhaustion in ovarian cancer [ bioRxiv, 2024, 2024.03.19.585657]	PubMed: 38562799
Knockout of the inhibitory receptor TIGIT enhances the antitumor response of ex vivo expanded NK cells and prevents fratricide with therapeutic Fc-active TIGIT antibodies [ J Immunother Cancer, 2023, 11(12)e007502]	PubMed: 38081778

FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS.

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We ensure that the product is shipped under conditions that will maintain the quality of the reagents. Upon receipt of the product, follow the storage recommendations on the product data sheet.