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Technical Data
| Formula | C7H4O3S |
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| Molecular Weight | 168.17 | CAS No. | 4991-65-5 | |
| Solubility (25°C)* | In vitro | DMSO | 34 mg/mL (202.17 mM) | |
| Water | 34 mg/mL (202.17 mM) | |||
| Ethanol | 34 mg/mL (202.17 mM) | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Tioxolone(Thioxolone) is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM. | ||
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| In vitro | Tioxolone is reported to possess cytostatic, antipsoriatic, antibacterial and anti-mycotic properties. Tioxolone is also added to some cosmetics (e.g. hair shampoos and skin cleansers), due to claims for its oil-regulating and antibacterial properties. The three-dimensional framework of Tioxolone is further stabilized by π-π interactions between the oxathiolone and benzene rings in partially overlapping molecules. [1] |
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| In vivo | Tioxolone, a Benzoxathiol derivatives, has been used in the local therapy of psoriasis vulgaris and acne, and also reported to have anti-bacterial, anti-mycotic, and cytostatic properties. [2] |
Protocol (from reference)
References
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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