Tedizolid Phosphate

Catalog No.S4641 Batch:S464101

Print

Technical Data

Formula

C17H16FN6O6P
Molecular Weight 450.32 CAS No. 856867-55-5
Solubility (25°C)* In vitro DMSO 22 mg/mL (48.85 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Tedizolid (TR-701FA) is an oxazolidinone-class antibiotic. Tedizolid phosphate is a phosphate ester prodrug of the active compound tedizolid.
In vitro Tedizolid (TR-700, formerly torezolid) is the active moiety of the prodrug tedizolid phosphate (TR-701), a next-generation oxazolidinone, with high potency against Gram-positive species, including methicillin-resistant Staphylococcus aureus (MRSA)[2]. Tedizolid is 4-fold more potent than linezolid against PRSP isolates in vitro[1].
In vivo Tedizolid has excellent penetration into pulmonary epithelial lining fluid (ELF). Tedizolid phosphate administered to mice orally or intravenously is effective in vivo against systemic infection with PRSP isolates. Oral tedizolid phosphate is also effective in vivo against pneumonia induced with a PSSP strain[1].

Protocol (from reference)

Animal Study:

[1]
  • Animal Models

    Male ICR mice

  • Dosages

    40 mg/kg of body weight, 13.33 mg/kg, 4.44 mg/kg, and 1.48 mg/kg

  • Administration

    oral administration; i.v.

Selleck's Tedizolid Phosphate has been cited by 1 publication

Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response. [ Sci Transl Med, 2019, 11(516)] PubMed: 31666400

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.