TD-165

Catalog No.S6994 Batch:S699401

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Technical Data

Formula

C46H59N7O8S
Molecular Weight 870.07 CAS No. 2305936-56-3
Solubility (25°C)* In vitro DMSO 100 mg/mL (114.93 mM)
Ethanol 100 mg/mL (114.93 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description TD-165 is a PROTAC-based cereblon (CRBN) degrader. TD-165 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group.
Targets
CRBN [1]
20.4 nM(DC50)
In vitro

Treatment with TD-165 causes a concentration-dependent decrease in the level of CRBN proteins by Western blot analysis.[1]
In vivo

TD-165 do not affect CRBN levels in the spleen, peripheral blood mononuclear cells (PBMCs), or liver of mice by immunoblotting, which might be attributable to the high plasma protein binding of TD-165. [1]

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    HEK293T cells

  • Concentrations

    0.1, 1, and 10 μM

  • Incubation Time

    24 h

  • Method

    HEK293T cells are treated with TD-158, TD-165, TD-343 or TD-487 (0.1, 1, and 10μM) for 24h, and VHL protein levels are analyzed by immunoblotting.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.