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Formula | C6H11NOS2 |
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Molecular Weight | 177.29 | CAS No. | 4478-93-7 | ||||||||
Solubility (25°C)* | In vitro | Water | 50 mg/mL (282.02 mM) | ||||||||
In vivo (Add solvents to the product individually and in order) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Sulforaphane is a naturally occurring isothiocyanate derived from the consumption of cruciferous vegetables, such as broccoli, cabbage, and kale. It is an inducer of Nrf2. Sulforaphane is also an inhibitor of histone deacetylase (HDAC) and NF-κB. Sulforaphane increases heme oxygenase-1 (HO-1) and reduces the levels of reactive oxygen species (ROS). Sulforaphane induces cell cycle arrest and apoptosis., | |||||
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Targets |
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In vitro | Sulforaphane, reactive oxygen species (ROS) inhibitor, decrease the autophagy induced by CC90003, while cell death strengthens, confirming that CC90003 induces autophagy by activating ROS/p53.[3] |
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In vivo | Natural isothiocyanate and potent NRF2 activator sulforaphane reverses diet-induced obesity through a predominantly, but not exclusively, NRF2-dependent mechanism that requires a functional leptin receptor signaling and hyperleptinemia.[4] |
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Density | 1.17 g/mL |
Cell Assay: |
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Animal Study: |
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Engineered Cas9 variants bypass Keap1-mediated degradation in human cells and enhance epigenome editing efficiency [ Nucleic Acids Res, 2024, gkae761] | PubMed: 39228373 |
Meningioma achieves malignancy and erastin-induced ferroptosis resistance through FOXM1-AURKA-NRF2 axis [ Redox Biol, 2024, 72:103137] | PubMed: 38642502 |
A novel effect of sulforaphane on promoting mouse granulosa cells proliferation via the NRF2-TKT pathway [ J Adv Res, 2024, S2090-1232(24)00422-3] | PubMed: 39341455 |
Druggable redox pathways against Mycobacterium abscessus in cystic fibrosis patient-derived airway organoids [ PLoS Pathog, 2023, 19(8):e1011559] | PubMed: 37619220 |
Druggable redox pathways against Mycobacterium abscessus in cystic fibrosis patient-derived airway organoids [ PLoS Pathog, 2023, 19(8):e1011559] | PubMed: 37619220 |
Identifying autophagy-related genes as potential targets for immunotherapy in tuberculosis [ Int Immunopharmacol, 2023, 118:109956] | PubMed: 36931175 |
Variable p53/Nrf2 crosstalk contributes to triptolide-induced hepatotoxic process [ Toxicol Lett, 2023, 379:67-75] | PubMed: 36990132 |
SARS-CoV-2 virus NSP14 Impairs NRF2/HMOX1 activation by targeting Sirtuin 1 [ Cell Mol Immunol, 2022, 19(8):872-882] | PubMed: 35732914 |
Sulforaphane reduces obesity by reversing leptin resistance [ Elife, 2022, 11e67368] | PubMed: 35323110 |
Downregulation of IL-8 and IL-10 by the Activation of Ca2+-Activated K+ Channel KCa3.1 in THP-1-Derived M2 Macrophages [ Int J Mol Sci, 2022, 23(15)8603] | PubMed: 35955737 |
RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.