Succinic acid

Catalog No.S3791 Batch:S379101

Technical Data

Formula	C₄H₆O₄
Molecular Weight	118.09	CAS No.	110-15-6
Solubility (25°C)*	In vitro	DMSO	23 mg/mL (194.76 mM)


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description	Succinic acid (1,4-Butandioic Acid, 1,2-Ethanedicarboxylic acid, Amber acid, Asuccin, Butanedioic acid) is a crystalline organic acid which occurs in living tissue as an intermediate in glucose metabolism.
In vivo	It has been reported that succinic acid had sedative effect (4000 mg/kg) and protective action against high pressure oxygen convulsion (1180 mg/kg). Succinic acid at dose of 1180 mg/kg produces significant decrease of the locomotor activity and hyperthermia and prolonged the pentobarbital sleeping time significantly in mice. Succinic acid is found to protect rats against audiogenic seizure and inhibit the electroshock seizure in mice, but not the convulsion induced by picrotoxin, strychnine and semicarbazide. Succinic acid (100-400 mg/kg) dose-dependently inhibits pentylenetetrazol chemical and amygdale kindled seizer. Succinic acid is widely distributed in the nervous systems. Succinic acid possesses anxiolytic effects in the elevated plus-maze, food neophobia and stress-induced hyperthermia models^[1].

Description

Succinic acid (1,4-Butandioic Acid, 1,2-Ethanedicarboxylic acid, Amber acid, Asuccin, Butanedioic acid) is a crystalline organic acid which occurs in living tissue as an intermediate in glucose metabolism.

In vivo

It has been reported that succinic acid had sedative effect (4000 mg/kg) and protective action against high pressure oxygen convulsion (1180 mg/kg). Succinic acid at dose of 1180 mg/kg produces significant decrease of the locomotor activity and hyperthermia and prolonged the pentobarbital sleeping time significantly in mice. Succinic acid is found to protect rats against audiogenic seizure and inhibit the electroshock seizure in mice, but not the convulsion induced by picrotoxin, strychnine and semicarbazide. Succinic acid (100-400 mg/kg) dose-dependently inhibits pentylenetetrazol chemical and amygdale kindled seizer. Succinic acid is widely distributed in the nervous systems. Succinic acid possesses anxiolytic effects in the elevated plus-maze, food neophobia and stress-induced hyperthermia models^[1].

Protocol (from reference)

Animal Study:^{^[1]}	Animal Models Male Swiss mice Dosages 3.0 or 6.0 mg/kg Administration p.o./i.p.

References

[1] Chen SW, et al. Life Sci. 2003, 73(25):3257-64.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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