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Formula | C20H31N3O
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Molecular Weight | 329.48 | CAS No. | 1629138-41-5 | |
Solubility (25°C)* | In vitro | Water | 66 mg/mL (200.31 mM) | |
Ethanol | 66 mg/mL (200.31 mM) | |||
DMSO | 60 mg/mL (182.1 mM) | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | SRI-011381 (C381) is a novel agonist of the TGF-beta signaling pathway for treatment of Alzheimer's disease.C381 physically targets the lysosome, promotes lysosomal acidification, increases breakdown of lysosomal cargo, and improves lysosome resilience to damage. | |
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Targets |
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In vitro | SRI-011381 partially reverses the effect of sodium ferulate (SF) on the expression of fibrosis-related proteins, by increasing TGF-β1, NALP3, collagen-1, and α-SMA expression.[2] |
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In vivo | SRI-011381, a small-molecule agonist of TGFβ signaling, has no effect on outflow tract (OFT) expansion in zebrafish, suggesting that hyperactivation of TGFβ signaling is not sufficient to induce aneurysm.[3] |
Cell Assay: |
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Animal Study: |
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Connexin 43 controls metastatic behavior in triple negative breast cancer through TGFβ1-Smad3-intergin αV signaling axis Based on optical image diagnosis [ SLAS Technol, 2024, 29(5):100190] | PubMed: 39299505 |
Latent TGFβ binding proteins 1 and 3 protect the larval zebrafish outflow tract from aneurysmal dilatation [ Dis Model Mech, 2022, dmm.046979] | PubMed: 35098309 |
Cartilage Endplate Stem Cells Transdifferentiate Into Nucleus Pulposus Cells via Autocrine Exosomes [ Front Cell Dev Biol, 2021, 9:648201] | PubMed: 33748142 |
MicroRNA-210-5p alleviates cardiac fibrosis via targeting transforming growth factor-beta type I receptor in rats on high sodium chloride (NaCl)-based diet [ Eur J Pharmacol, 2021, 912:174587] | PubMed: 34678242 |
MMP11 promotes the proliferation and progression of breast cancer through stabilizing Smad2 protein [ Oncol Rep, 2021, 45(4)16] | PubMed: 33649832 |
RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.