Spermidine

Catalog No.S3569 Batch:S356901

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Technical Data

Formula

C7H19N3
Molecular Weight 145.25 CAS No. 124-20-9
Solubility (25°C)* In vitro  
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Biological Activity

Description Spermidine is a natural polyamine that stimulates cytoprotective macroautophagy/autophagy.
In vitro

Spermidine and spermine significantly increases the viability and proliferation of SKOV-3 cells in a time-dependent manner, and decreases the apoptotic effect of Difluoromethylornithine (DFMO) in SKOV-3 cells. [1]
In vivo

Spermidine, a selective activator of TC45, rescues exacerbated phenotype of Hematopoietic stem and progenitor cells (HSPCs) in IFN‐γ‐treated Hemgn-/- mice.
Density 1g/ml

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    SKOV-3 cells

  • Concentrations

    50 μM

  • Incubation Time

    1–5 days

  • Method

    SKOV-3 cells are incubated with 50 μM spermidine or spermine for 1–5 days, and then cell viability and proliferation are determined using the PrestoBlue or CellTiter-Glo assays, respectively.

Selleck's Spermidine has been cited by 6 publications

Metabolic support by macrophages sustains colonic epithelial homeostasis [ Cell Metab, 2023, S1550-4131(23)00341-8] PubMed: 37804836
Rebalance of the Polyamine Metabolism Suppresses Oxidative Stress and Delays Senescence in Nucleus Pulposus Cells [ Oxid Med Cell Longev, 2022, 2022:8033353] PubMed: 35178160
Screening Health-Promoting Compounds for Their Capacity to Induce the Activity of FOXO3 [ J Gerontol A Biol Sci Med Sci, 2022, 77-8:1485-1493] PubMed: 34508571
Hemgn Protects Hematopoietic Stem and Progenitor Cells Against Transplantation Stress Through Negatively Regulating IFN-γ Signaling [ Adv Sci (Weinh), 2021, e2103838] PubMed: 34923767
Difluoromethylornithine Induces Apoptosis through Regulation of AP-1 Signaling via JNK Phosphorylation in Epithelial Ovarian Cancer [ Int J Mol Sci, 2021, 22(19)10255] PubMed: 34638596
Difluoromethylornithine Induces Apoptosis through Regulation of AP-1 Signaling via JNK Phosphorylation in Epithelial Ovarian Cancer [ Int J Mol Sci, 2021, 22(19), 10255] PubMed: None

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.