Sodium Lauryl Sulfoacetate

Catalog No.S3801 Batch:S380102

Technical Data

Formula	C₁₄H₂₇O₅S.Na
Molecular Weight	330.42	CAS No.	1847-58-1
Solubility (25°C)*	In vitro	DMSO	2 mg/mL (6.05 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description	Sodium Lauryl Sulfoacetate, the active compound of the Houttuynia plant, is mainly used for treating purulent skin infections, respiratory tract infections, including pneumonia in elderly patients, and chronic bronchitis.
In vitro	Treatment with Sodium Lauryl Sulfoacetate results in an increase in the expression of c-Fos protein in macrophages, while the phosphorylation level of extracellular signal-related kinase 1/2 (ERK1/2) is not affected by the treatment^[2].
In vivo	Sodium Lauryl Sulfoacetate has been shown to protect against cationized bovine serum albumin (C-BSA)-induced glomerulonephritis in BALB/C mice through the suppression of the urine protein, morphological character and monocyte chemotactic protein 1 (MCP-1). In addition, Sodium Lauryl Sulfoacetate treatment has been shown to induce a respiratory burst and to increase the concentration of free calcium in macrophages, as well as increase IL-2 within T-cells. Sodium Lauryl Sulfoacetate in the serum, stomach and intestine can be detected immediately by GC at 0.5 h. The concentration of Sodium Lauryl Sulfoacetate in the stomach gradually increases from 0.5–2 h, but is drastically reduced at 4 h. Furthermore, the concentration in the serum and intestine at 1–4 h decreases in a time-dependent manner, indicating that Sodium Lauryl Sulfoacetate can be quickly absorbed into the circulatory system and intestine and might be quickly distributed to other organs, such as trachea, lung, brain, heart and kidney^[2].

Protocol (from reference)

Cell Assay:^{^[1]}	Cell lines synovial cells Concentrations 25, 50, 100, 200 μg/ml Incubation Time seven days Method The primary cells are equally divided into five groups as follows: the control group (group 1), cells treated with 25 μg/ml Sodium Lauryl Sulfoacetate (group 2), 50 μg/ml Sodium Lauryl Sulfoacetate (group 3), 100 μg/ml Sodium Lauryl Sulfoacetatee (group 4) and 200 μg/ml Sodium Lauryl Sulfoacetate (group 5). Group 1 is administered an equivalent amount of normal saline (NS), whilst groups 2 to 5 are treated with corresponding amounts of Sodium Lauryl Sulfoacetate. NS and Sodium Lauryl Sulfoacetate are administered daily for 7 days by transfer pipette. Following the final administration, the five groups of synovial cells are measured using an MTT assay for analysis of the growth inhibitory rate of SH on synovial proliferation.

Cell Assay:^{^[1]}

Cell lines
synovial cells
Concentrations
25, 50, 100, 200 μg/ml
Incubation Time
seven days
Method
The primary cells are equally divided into five groups as follows: the control group (group 1), cells treated with 25 μg/ml Sodium Lauryl Sulfoacetate (group 2), 50 μg/ml Sodium Lauryl Sulfoacetate (group 3), 100 μg/ml Sodium Lauryl Sulfoacetatee (group 4) and 200 μg/ml Sodium Lauryl Sulfoacetate (group 5). Group 1 is administered an equivalent amount of normal saline (NS), whilst groups 2 to 5 are treated with corresponding amounts of Sodium Lauryl Sulfoacetate. NS and Sodium Lauryl Sulfoacetate are administered daily for 7 days by transfer pipette. Following the final administration, the five groups of synovial cells are measured using an MTT assay for analysis of the growth inhibitory rate of SH on synovial proliferation.

References

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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