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Formula | C28H29Cl2N3OS |
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Molecular Weight | 526.52 | CAS No. | 2095432-58-7 | |
Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (189.92 mM) | |
Water | 100 mg/mL (189.92 mM) | |||
Ethanol | 40 mg/mL (75.97 mM) | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | SAG (Smoothened Agonist) HCl is a cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells. | ||
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In vitro | SAG regulates Smo activity by binding directly to the Smo heptahelical bundle. [1] SAG induces Smo-dependent signaling through Gli in a GRK2-dependent way. [2] SAG also (1 nM) induces proliferation of neuronal and glial precursors without affecting the differentiation pattern of newly produced cells. [3] |
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In vivo | In the adult rat hippocampus, the intracerebroventricular administration of SAG (2.5 nM) significantly increases the number of newly generated cells and extends survival of hippocampal cells. [3] In mice, SAG (20 μg/g, i.p.) effectively prevents GC-induced neonatal cerebellar developmental abnormalities. [4] |
Kinase Assay: |
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Animal Study: |
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Data from [Data independently produced by , , J Pain Res, 2018, 11:649-659]
Jag1/2 maintain esophageal homeostasis and suppress foregut tumorigenesis by restricting the basal progenitor cell pool [ Nat Commun, 2024, 15(1):4124] | PubMed: 38750026 |
Jag1/2 maintain esophageal homeostasis and suppress foregut tumorigenesis by restricting the basal progenitor cell pool [ Nat Commun, 2024, 15(1):4124] | PubMed: 38750026 |
An epilepsy-associated CILK1 variant compromises KATNIP regulation and impairs primary cilia and Hedgehog signaling [ bioRxiv, 2024, 2024.05.14.594243] | PubMed: 38798407 |
Spatially controlled construction of assembloids using bioprinting [ Nat Commun, 2023, 14(1):4346] | PubMed: 37468483 |
Spatially controlled construction of assembloids using bioprinting [ Nat Commun, 2023, 14(1):4346] | PubMed: 37468483 |
Highly reproducible and cost-effective one-pot organoid differentiation using a novel platform based on PF-127 triggered spheroid assembly [ Biofabrication, 2023, 15(4).] | PubMed: 37552975 |
Selective induction of human renal interstitial progenitor-like cell lineages from iPSCs reveals development of mesangial and EPO-producing cells [ Cell Rep, 2023, S2211-1247(23)01614-5] | PubMed: 38237600 |
Heat promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathway [ iScience, 2023, 26(5):106749] | PubMed: 37216091 |
Acquisition of neural fate by combination of BMP blockade and chromatin modification [ iScience, 2023, 26(10):107887] | PubMed: 37771660 |
Acquisition of neural fate by combination of BMP blockade and chromatin modification [ iScience, 2023, 26(10):107887] | PubMed: 37771660 |
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.