SKF38393 HCl

Catalog No.S7993 Batch:S799301

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Technical Data

Formula

C16H17NO2 . HCl

Molecular Weight 291.77 CAS No. 62717-42-4
Solubility (25°C)* In vitro DMSO 58 mg/mL (198.78 mM)
Ethanol 6 mg/mL (20.56 mM)
Water 5 mg/mL (17.13 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description SKF38393 HCl is a selective dopamine D1/D5 receptor agonist.
Targets
dopamine D1 receptor [1] D5 receptor [1]
In vitro SKF38393 (50-100 μM) induces long-lasting synaptic potentiation in a protein synthesis-dependent manner. [1] In rat prefrontal cortical neurons in vitro, SKF 38393 mimicks the effects of DA on I(NaP), and modulates a persistent sodium current. [2] In the auditory cortex, SKF38393 affects long-term memory formation and consolidation by activating the downstream effectors adenylyl cyclase and phospholipase C-prominent proteomic alterations. [4]
In vivo SKF 38393(6 mg/kg, i.p.) prevents the scopolamine-induced impairment of performance of a T-maze working memory task. [3] In adult male NMRI mice, SKF38393 (1 μg/mouse) impaires context-dependent fear learning. [5]

Protocol (from reference)

Animal Study:[3]
  • Animal Models

    Male Wistar rats

  • Dosages

    6 mg/kg

  • Administration

    i.p.

Selleck's SKF38393 HCl has been cited by 3 publications

Apomorphine is a potent inhibitor of ferroptosis independent of dopaminergic receptors [ Sci Rep, 2024, 14(1):4820] PubMed: 38413694
Cry1Δ11 mutation induces ADHD-like symptoms through hyperactive dopamine D1 receptor signaling [ JCI Insight, 2023, 8(16)e170434] PubMed: 37606043
Cry1Δ11 mutation induces ADHD-like symptoms through hyperactive dopamine D1 receptor signaling [ JCI Insight, 2023, 8(16)e170434] PubMed: 37606043

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.