SJ-172550

Catalog No.E0051 Batch:E005101

Print

Technical Data

Formula

C₂₂H₂₁ClN₂O₅
Molecular Weight 428.87 CAS No. 431979-47-4
Solubility (25°C)* In vitro DMSO 86 mg/mL (200.52 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description SJ 172550 is the first MDMX inhibitor that binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified.
Targets
MDMX [1]
In vitro

SJ-172550 binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified. The effect of SJ-172550 is additive when combined with an MDM2 inhibitor nutlin-3a.[1]

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    Retinoblastoma cells, ML-1 leukemia cells

  • Concentrations

    20 μM

  • Incubation Time

    20 h

  • Method

    Retinoblastoma cells and ML-1 leukemia cells (with wild-type p53) are exposed to SJ-172550 (20 μm) for 20 h. And then the p53 and activated caspase-3 levels are analyzed by immunofluorescence. Nutlin-3a (5 μm; 20 h) is used for as the positive controls. DMSO is used as the negative control.

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.