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Technical Data
| Formula | C22H20N4OS2 |
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| Molecular Weight | 420.55 | CAS No. | 709002-46-0 | |
| Solubility (25°C)* | In vitro | DMSO | 84 mg/mL (199.73 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM. | ||
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| Targets |
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| In vitro | SirReal2 selectively inhibits Sirt2 via a Sirt2-specific amino acid network, and induces a tubulin hyperacetylation and a significant depletion of BubR1 in HeLa cells. [1] | ||
| In vivo | In vivo, SirReal2 inhibits Sirt2 activity without affecting the activity of the other Class-I sirtuins Sirt1 and Sirt3. [1] |
Protocol (from reference)
Selleck's SirReal2 has been cited by 11 publications
| Effects of Dimerization on the Deacylase Activities of Human SIRT2 [ Biochemistry, 2023, 10.1021/acs.biochem.3c00381] | PubMed: 37966275 |
| Effects of Hst3p inhibition in <i>Candida albicans</i>: a genome-wide H3K56 acetylation analysis [ Front Cell Infect Microbiol, 2022, 12:1031814] | PubMed: 36389164 |
| The Anticancer Effect of a Flavonoid-Rich Extract of Bergamot Juice in THP-1 Cells Engages the SIRT2/AKT/p53 Pathway [ Pharmaceutics, 2022, 14-102168] | PubMed: 36297603 |
| The SIRT2 Pathway Is Involved in the Antiproliferative Effect of Flavanones in Human Leukemia Monocytic THP-1 Cells [ Biomedicines, 2022, 10-102383] | PubMed: 36289647 |
| LncRNA LncHrt preserves cardiac metabolic homeostasis and heart function by modulating the LKB1-AMPK signaling pathway [ Basic Res Cardiol, 2021, 116(1):48] | PubMed: 34379189 |
| LncRNA LncHrt preserves cardiac metabolic homeostasis and heart function by modulating the LKB1-AMPK signaling pathway [ Basic Res Cardiol, 2021, 116(1):48] | PubMed: 34379189 |
| SIRT1 inhibitors mitigate radiation-induced GI syndrome by enhancing intestinal-stem-cell survival [ Cancer Lett, 2020, 501:20-30] | PubMed: 33359449 |
| A novel role of SIRT2 in regulating gap junction communications via connexin-43 in bovine cumulus-oocyte complexes. [ J Cell Physiol, 2020, 10.1002] | PubMed: 32039484 |
| SIRT2 Inhibition Results in Meiotic Arrest, Mitochondrial Dysfunction, and Disturbance of Redox Homeostasis during Bovine Oocyte Maturation. [ Int J Mol Sci, 2019, 20(6)] | PubMed: 30889926 |
| SIRT2 plays a novel role on progesterone, estradiol and testosterone synthesis via PPARs/LXRα pathways in bovine ovarian granular cells [Xu D J Steroid Biochem Mol Biol, 2019, 185:27-38] | PubMed: 30009951 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.