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Technical Data
| CAS No. | 2072873-06-2 |
|---|---|
| Formulation | PBS Buffer, PH 7.4 |
| Isotype | Human IgG4, κ |
| Source | CHO cells |
| Storage (From the date of receipt) |
Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles. |
| Purity | 99% |
| Protein concentration | 5.81 mg/ml |
| Endotoxin Level | <1 EU/mg |
Biological Activity
| Description | Sintilimab (anti-PD-1, IBI 308) is a fully human IgG4 monoclonal antibody that binds to PD-1 on the surface of T-cells, blocks the PD-1/PD-Ligand 1 (PD-L1) pathway, and reactivates T-cells to kill cancer cells. |
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Selleck's Sintilimab (anti-PD-1) has been cited by 1 publication
| Intratumoral CXCL13+ CD160+ CD8+ T cells promote the formation of tertiary lymphoid structures to enhance the efficacy of immunotherapy in advanced gastric cancer [ J Immunother Cancer, 2024, 12(9)e009603] | PubMed: 39244216 |
FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS.
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products are stable under the recommended conditions. Products are sometimes shipped at a temperature that differs from the recommended storage temperature. Short-term storage of many products are stable in the short-term at temperatures that differ from that required for long-term storage.
We ensure that the product is shipped under conditions that will maintain the quality of the reagents. Upon receipt of the product, follow the storage recommendations on the product data sheet.