Silmitasertib (CX-4945) sodium salt

Catalog No.S0707 Batch:S070704

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Technical Data

Formula

C19H11ClN3NaO2

Molecular Weight 371.75 CAS No. 1309357-15-0
Solubility (25°C)* In vitro DMSO 37 mg/mL (99.52 mM)
Water 5 mg/mL (13.44 mM)
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Silmitasertib (CX-4945) sodium salt is a potent, orally bioavailable and selective inhibitor of casein kinase 2 (CK2) with IC50 of 1 nM against CK2α and CK2α'.
Targets
CK2α [1]
(Cell-free assay)
CK2α' [1]
(Cell-free assay)
1 nM 1 nM

Protocol (from reference)

Animal Study:

[1]

  • Animal Models

    Female CrTac:Ncr-Foxn1 mice

  • Dosages

    25 mg/kg

  • Administration

    o.g.

Selleck's Silmitasertib (CX-4945) sodium salt has been cited by 64 publications

CK2 activity is crucial for proper glucagon expression [ Diabetologia, 2024, 10.1007/s00125-024-06128-1] PubMed: 38503901
Mitochondrial ALDH2 improves ß-cell survival and function against doxorubicin-induced apoptosis by targeting CK2 signaling [ J Diabetes Investig, 2024, 15(6):684-692] PubMed: 38713732
AhR promotes phosphorylation of ARNT isoform 1 in human T cell malignancies as a switch for optimal AhR activity [ Proc Natl Acad Sci U S A, 2022, 119(12):e2114336119] PubMed: 35290121
Inhibition of casein kinase 2 sensitizes mantle cell lymphoma to venetoclax through MCL-1 downregulation [ Haematologica, 2022, 10.3324/haematol.2022.281668] PubMed: 36226498
CK2 blockade alleviates liver fibrosis by suppressing activation of hepatic stellate cells via the Hedgehog pathway [ Br J Pharmacol, 2022, 10.1111/bph.15945] PubMed: 36070072
Protein Kinase CK2 acts as a molecular brake to control NADPH oxidase 1 activation and colon inflammation [ Cell Mol Gastroenterol Hepatol, 2022, S2352-345X(22)00003-0] PubMed: 35031518
Anti-adipogenic and Pro-lipolytic Effects on 3T3-L1 Preadipocytes by CX-4945, an Inhibitor of Casein Kinase 2 [ Int J Mol Sci, 2022, 23(13)7274] PubMed: 35806278
Inhibitory Response to CK II Inhibitor Silmitasertib and CDKs Inhibitor Dinaciclib Is Related to Genetic Differences in Pancreatic Ductal Adenocarcinoma Cell Lines [ Int J Mol Sci, 2022, 23(8)4409] PubMed: 35457227
Targeting AKT and CK2 represents a novel therapeutic strategy for SMO constitutive activation-driven medulloblastoma [ CNS Neurosci Ther, 2022, 10.1111/cns.13835] PubMed: 35419951
CIGB-300 Peptide Targets the CK2 Phospho-Acceptor Domain on Human Papillomavirus E7 and Disrupts the Retinoblastoma (RB) Complex in Cervical Cancer Cells [ Viruses, 2022, 14(8)1681] PubMed: 36016303

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.