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Technical Data
| Formula | C22H30N6O4S.xCH4O3S |
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| Molecular Weight | 474.58(free base) | CAS No. | 1308285-21-3 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL | |
| Water | 100 mg/mL | |||
| Ethanol | 4 mg/mL | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Sildenafil Mesylate(UK-92480 Mesylate) is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5. | |
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| In vivo | Chronic sildenafil treatment increases the detumescence phase in young and aged rats (p<0.05), although aged rats show a greater increase than young rats. Baseline cavernous PDE5 expression and activity are greater in aged vs young rats (p<0.05). After chronic sildenafil treatment cavernous PDE5 expression is increased in young (p<0.05) but not in aged rats. Chronic and acute sildenafil treatment similarly inhibits PDE5 activity in the penis of young and aged rats (p<0.05), coincident with its free plasma concentrations equivalent to clinically therapeutic ranges[2]. |
Protocol (from reference)
| Animal Study: |
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References
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Selleck's Sildenafil Mesylate has been cited by 4 publications
| Additive protective effects of sacubitril/valsartan and bosentan on vascular remodelling in experimental pulmonary hypertension [ Cardiovasc Res, 2021, 117(5):1391-1401] | PubMed: 32653925 |
| Kyoto probe-1 reveals phenotypic differences between mouse ES cells and iTS-P cells [ Sci Rep, 2020, 10(1):18084] | PubMed: 33093580 |
| Multi-kinase inhibitors can associate with heat shock proteins through their NH2-termini by which they suppress chaperone function [ Oncotarget, 2016, 7(11):12975-96] | PubMed: 26887051 |
| Celecoxib enhances [sorafenib + sildenafil] lethality in cancer cells and reverts platinum chemotherapy resistance [ Cancer Biol Ther, 2015, 16(11):1660-70] | PubMed: 26417912 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.