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Formula | C28H33ClN4O3 |
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Molecular Weight | 509.04 | CAS No. | 1613695-14-9 | ||||
Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (196.44 mM) | ||||
Ethanol | 100 mg/mL (196.44 mM) | ||||||
Water | Insoluble | ||||||
In vivo (Add solvents to the product individually and in order) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | SGC-CBP30 is a potent CREBBP/EP300 inhibitor with IC50 of 21 nM and 38 nM in cell-free assays, respectively. Exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2) respectively. | ||||
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Targets |
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In vitro | As a CREBBP/EP300-selective chemical probe, SGC-CBP30 shows moderate cytotoxicity in U2OS cells and HeLa cells. [1] |
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Features | CREBBP/EP300-selective chemical probe. |
Cell Assay: |
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Animal Study: |
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Data from [Data independently produced by , , Cell, 2018, 175(1):186-199]
Data from [Data independently produced by , , J Proteome Res, 2017, 16:1743−1752]
Data from [Data independently produced by , , Biomed Pharmacother, 2018, 106:1727-1733]
High-throughput discovery and characterization of viral transcriptional effectors in human cells [ Cell Syst, 2023, 14(6):482-500.e8] | PubMed: 37348463 |
NFYC-37 promotes tumor growth by activating the mevalonate pathway in bladder cancer [ Cell Rep, 2023, 42(8):112963] | PubMed: 37561631 |
Chemical-induced epigenome resetting for regeneration program activation in human cells [ Cell Rep, 2023, 42(6):112547] | PubMed: 37224020 |
Long non-coding RNA ACTA2-AS1 promotes ductular reaction by interacting with the p300/ELK1 complex [ J Hepatol, 2022, 76(4):921-933] | PubMed: 34953958 |
Structural insights into p300 regulation and acetylation-dependent genome organisation [ Nat Commun, 2022, 13(1):7759] | PubMed: 36522330 |
DBC1 is a key positive regulator of enhancer epigenomic writers KMT2D and p300 [ Nucleic Acids Res, 2022, gkac585] | PubMed: 35801925 |
Acetylation of Checkpoint suppressor 1 enhances its stability and promotes the progression of triple-negative breast cancer [ Cell Death Discov, 2022, 8(1):474] | PubMed: 36450706 |
Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer [ Clin Epigenetics, 2022, 14(1):147] | PubMed: 36371227 |
Transcriptional Activation of Ecdysone-Responsive Genes Requires H3K27 Acetylation at Enhancers [ Int J Mol Sci, 2022, 23(18)10791] | PubMed: 36142704 |
ecDNA hubs drive cooperative intermolecular oncogene expression [ Nature, 2021, 10.1038/s41586-021-04116-8] | PubMed: 34819668 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.