Sertraline HCl

Catalog No.S4053 Batch:S405304

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Technical Data

Formula

C17H17Cl2N.HCl
Molecular Weight 342.69 CAS No. 79559-97-0
Solubility (25°C)* In vitro DMSO 69 mg/mL (201.34 mM)
Ethanol 17 mg/mL (49.6 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
30%PEG400 0.5%Tween80 5%propylene glycol
5.0mg/ml Taking the 1 mL working solution as an example, add 300 μL of 16.67 mg/ml clarified PEG400 stock solution to 5 μL of Tween80, mix evenly to clarify it; add 50 μL Propylene glycol to the above system, mix evenly to clarify it; then continue to add 645 μL ddH2O Dilute to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Sertraline HCl (CP-51974-1) is a 5-HT antagonist with Ki of 13 nM.
Targets
5-HT [1]
13 nM(Ki)
In vitro Sertraline exhibits better selectivity for inhibiting 5-HT uptake relative to NE uptake than fluvoxamine, zimelidine, norzimelidine, fluoxetine or chlorimipramine. However, Sertraline is less selective for blocking 5-HT uptake, relative to DA uptake than these agents. [1]
In vivo Sertraline HCl (32μmol/kg i.p.) inhibits serotonin uptake into striatal synaptosomes from rats by more than 50%. Sertraline HCl is 6 times more potent than chlorimipramine and 60 times more potent than amitriptyline in reversing the 5-HT depletion elicited by PCA. Acute and repeated dosing of sertraline decreased serotonin content of whole blood. Sertraline HCl strongly reduces immobility of mice in the Porsolt swim test for antidepressants. After repeated dosing in rats, sertraline HCl diminishes the cyclic AMP response of limbic forebrain adenylate cyclase to norepinephnne, as well as the binding of [3H]dihydroalprenolol to cortical membranes. [1]

Protocol (from reference)

Animal Study:

[1]
  • Animal Models

    Rats, Mice

  • Dosages

    --

  • Administration

    i.p.

Selleck's Sertraline HCl has been cited by 4 publications

SSRI antidepressant citalopram reverses the Warburg effect to inhibit hepatocellular carcinoma by directly targeting GLUT1 [ Cell Rep, 2024, 43(10):114818] PubMed: 39388353
Inhibition of Arenaviruses by Combinations of Orally Available Approved Drugs [ Antimicrob Agents Chemother, 2021, AAC.01146-20] PubMed: 33468464
Effect of SSRI exposure on the proliferation rate and glucose uptake in breast and ovary cancer cell lines [ Sci Rep, 2021, 11(1):1250] PubMed: 33441923
In vitro activity of non-antibiotic drugs against Staphylococcus aureus clinical strains [ J Glob Antimicrob Resist, 2021, 27:167-171] PubMed: 34560306

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.