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Formula | C20H15F2NO |
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Molecular Weight | 323.34 | CAS No. | 289656-45-7 | ||||
Solubility (25°C)* | In vitro | DMSO | 65 mg/mL (201.02 mM) | ||||
Ethanol | 6 mg/mL (18.55 mM) | ||||||
Water | Insoluble | ||||||
In vivo (Add solvents to the product individually and in order) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Senicapoc (ICA-17043) is a Gardos channel(Ca2+-activated K+ channel; KCa3.1) blocker with an IC50 of 11 nM and produces dose-dependent increases in hemoglobin and decreases in markers of hemolysis. Senicapoc blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 nM and inhibits RBC dehydration with IC50 of 30 nM. | ||
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Targets |
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In vitro | Senicapoc (ICA-17043) is shown to block the Gardos channel of mouse (C57 Black) RBCs with an IC50 of 50±6 nM.Senicapoc blocks this increase in cellular hemoglobin concentration in human RBCs in a concentration-dependent fashion.[1] |
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In vivo | Senicapoc (ICA-17043) administration produces a significant decrease in Gardos channel activity measured at day 11 and 21 and is associated with a corresponding increase in red cell K+ content without changes in Na+ content. Senicapoc (10 mg/kg, twice a day) induces a significant increase in Hct after 11 days of dosing in the SAD mouse.[1] |
Cell Assay: |
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Animal Study: |
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Phospholipid scrambling induced by an ion channel/metabolite transporter complex [ Nat Commun, 2024, 15(1):7566] | PubMed: 39217145 |
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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