SCR130

Catalog No.S9775 Batch:S977501

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Technical Data

Formula

C19H13Cl2N3O2S
Molecular Weight 418.30 CAS No. 2377858-38-1
Solubility (25°C)* In vitro DMSO 84 mg/mL (200.81 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description SCR130 is a novel DNA repair inhibitor with IC50s of 14 μM in Reh cells and 2 μM in Nalm6 cells. SCR130 specifically inhibits DNA Ligase IV‐mediated joining with minimal or no effect on Ligase III and Ligase I mediated joining.
Targets
DNA repair [1]
(in Nalm6 cells)
2 μM
In vitro

SCR130 is a new a novel inhibitor of nonhomologous end-joining (NHEJ) by leading to loss of mitochondrial membrane potential leading to cell death by activating both intrinsic and extrinsic pathways of apoptosis, showing the IC50 of 14.1 μM in Reh cells and 2.2 μM in Nalm6 cells.<sup><a class="sref" href="#s_ref">[1]</a></sup>

Protocol (from reference)

Cell Assay:

<sup><a class="sref" href="#s_ref">[1]</a></sup>
  • Cell lines

    Reh, HeLa, CEM, Nalm6 and N114 cells

  • Concentrations

    0.1, 0.5, 1, 2, 5, 10, 50, and 100 μM

  • Incubation Time

    48 h

  • Method

    Effect of the inhibitors on Nalm6, Reh, HeLa, CEM, and N114 cell lines was determined by Trypan Blue dye exclusion assay

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.