Schizandrol A

Catalog No.S3823 Batch:S382301

Technical Data

Formula	C₂₄H₃₂O₇
Molecular Weight	432.51	CAS No.	7432-28-2
Solubility (25°C)*	In vitro	DMSO	86 mg/mL (198.83 mM)


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description	Schizandrol A is one of the effective components in the dried fruit of Schizandra chinensis Bail and works by increasing dopamine, a neurotransmitter, in the brain.
In vivo	Schizandrol A could improve the learning-memory dysfunction in mice induced by sodium pentobarbital intraperitoneally injected, and its protective mechanism is related to the effect of lowering oxidative damage and inhibiting the cell apoptosis through up-regulating the expression of Bcl-2 and down-regulating the expression of bax and improving the synthesis of neurotransmitters through increasing the expression of ChAT in the hippocampal CA1 region^[2].

Description

Schizandrol A is one of the effective components in the dried fruit of Schizandra chinensis Bail and works by increasing dopamine, a neurotransmitter, in the brain.

In vivo

Schizandrol A could improve the learning-memory dysfunction in mice induced by sodium pentobarbital intraperitoneally injected, and its protective mechanism is related to the effect of lowering oxidative damage and inhibiting the cell apoptosis through up-regulating the expression of Bcl-2 and down-regulating the expression of bax and improving the synthesis of neurotransmitters through increasing the expression of ChAT in the hippocampal CA1 region^[2].

Protocol (from reference)

Cell Assay:^{^[1]}	Cell lines The SH-SY5Y neuronal cell line Concentrations 1 or 3 μg/ml Incubation Time 4 d Method After 24 h of incubation with or without schisandrin treatment, SH-SY5Y cells are seeded onto 96-well culture plates. Metallothionein (MTT) is added and absorbance values are continually measured for 4 d. All assays are conducted in triplicate. Data are expressed as percent viability. Rate of SH-SY5Y cells proliferation is calculated from optical density (OD) values.
Animal Study:^{^[2]}	Animal Models Mice Dosages 0.5, 1.0, 2.0 g/kg/d Administration by oral gavage

Cell Assay:^{^[1]}

Cell lines
The SH-SY5Y neuronal cell line
Concentrations
1 or 3 μg/ml
Incubation Time
4 d
Method
After 24 h of incubation with or without schisandrin treatment, SH-SY5Y cells are seeded onto 96-well culture plates. Metallothionein (MTT) is added and absorbance values are continually measured for 4 d. All assays are conducted in triplicate. Data are expressed as percent viability. Rate of SH-SY5Y cells proliferation is calculated from optical density (OD) values.

Animal Study:^{^[2]}

Animal Models
Mice
Dosages
0.5, 1.0, 2.0 g/kg/d
Administration
by oral gavage

References

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.