Schisandrin B

Catalog No.S3600 Batch:S360005

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Technical Data

Formula

C23H28O6
Molecular Weight 400.46 CAS No. 61281-37-6
Solubility (25°C)* In vitro DMSO 80 mg/mL (199.77 mM)
Ethanol 20 mg/mL (49.94 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5% DMSO 95% corn oil
4.0mg/ml Taking the 1 mL working solution as an example, add 50 μL of 80 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
4.0mg/ml Taking the 1 mL working solution as an example, add 50 μL of 80 mg/ml clarified DMSO stock solution to 400 μL PEG300, mix evenly to clarify it; add 50 μL Tween80 to the above system, mix evenly to clarify it; then continue to add 500 μL ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. It is a kind of ATR and P-gp inhibitor with high safety.
Targets
P-gp [10]
(Cell-based assay)		 ATR [2]
7.25 μM
In vitro Schisandrin B is able to induce high level of apoptosis in human hepatic carcinoma cells and human leukemia cells. [1] Schisandrin B decreases the viability of adenocarcinoma cells after UV exposure. The specific inhibitory effect of schisandrin B on ATR protein kinase activity (a DNA repair enzyme) following DNA damage in cells may be useful in anti-cancer therapy. [2] Schisandrin B is found to be the only molecule being a cardioprotective agent as well as a dual inhibitor of P-glycoprotein and multidrug resistance-associated protein 1, which is potentially applicable to treat cancers, especially those displaying multidrug resistance. [3] [4]
In vivo Schisandrin B can protect liver against toxicant challenge. Schisandrin B pretreatment protects against carbon tetrachloride- or TNFα-induced liver damage in mice. [5] [6] [7] Further studies demonstrate the protective effect of schisandrin B on free radical-induced damage in various vital organs, including the heart, liver, kidney, brain and skin. [8] Moreover, schisandrin B is found to attenuate cancer invasion and metastasis via inhibiting epithelial mesenchymal transition at the step of local invasion. [9]

Protocol (from reference)

Selleck's Schisandrin B has been cited by 8 publications

Unveiling the Renoprotective Mechanisms of Schisandrin B in Ischemia-Reperfusion Injury Through Transcriptomic and Pharmacological Analysis [ Drug Des Devel Ther, 2024, 18:4241-4256] PubMed: 39323973
Screening of Botanical Drugs against SARS-CoV-2 Entry Reveals Novel Therapeutic Agents to Treat COVID-19 [ Viruses, 2022, 14(2)353] PubMed: 35215943
Schisandrin B-mediated TH17 cell differentiation attenuates bowel inflammation [ Pharmacol Res, 2021, 166:105459] PubMed: 33545313
Schisandrin B regulates macrophage polarization and alleviates liver fibrosis via activation of PPARγ [ Ann Transl Med, 2021, 9(19):1500] PubMed: 34805362
Schisandrin B ameliorates non-alcoholic liver disease through anti-inflammation activation in diabetic mice [ Drug Dev Res, 2021, 10.1002/ddr.21905] PubMed: 34927282
Schisandrin B improves cerebral ischemia and reduces reperfusion injury in rats through TLR4/NF-κB signaling pathway inhibition [ Neurol Res, 2020, 42(8):693-702] PubMed: 32657248
An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447] PubMed: 30900754
Schisandrin B Ameliorates Myocardial Ischemia/Reperfusion Injury Through Attenuation of Endoplasmic Reticulum Stress-Induced Apoptosis [Zhang W, et al. Inflammation, 2017, 40(6):1903-1911] PubMed: 28748322

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.