SCH-23390 hydrochloride

Catalog No.S0476 Batch:S047601

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Technical Data

Formula

C17H19Cl2NO

Molecular Weight 324.24 CAS No. 125941-87-9
Solubility (25°C)* In vitro DMSO 65 mg/mL (200.46 mM)
Ethanol 25 mg/mL (77.1 mM)
Water 20 mg/mL (61.68 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description SCH-23390 hydrochloride (R-(+)-SCH-23390, SCH-23390) is a highly potent and selective dopamine D1-like receptor antagonist with Ki of 0.2 nM and 0.3 nM for the D1 and D5 dopamine receptor subtypes, respectively. SCH-23390 hydrochloride is a potent and high efficacy agonist at h5-HT2C receptors with Ki of 9.3 nM. SCH-23390 hydrochloride directly inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with IC50 of 268 nM.
Targets
D1 dopamine receptor [1]
(Cell-free assay)
D5 dopamine receptor [1]
(Cell-free assay)
h5-HT2C receptor [2]
(Cell-free assay)
GIRK [3]
(Cell-free assay)
0.2 nM(Ki) 0.3 nM(Ki) 9.3 nM(Ki) 268 nM

Protocol (from reference)

Selleck's SCH-23390 hydrochloride has been cited by 3 publications

Dopamine receptor 1 on CaMKII-positive neurons within claustrum mediates adolescent cocaine exposure-induced anxiety-like behaviors and electro-acupuncture therapy [ Theranostics, 2023, 13(10):3149-3164] PubMed: 37351159
Cry1Δ11 mutation induces ADHD-like symptoms through hyperactive dopamine D1 receptor signaling [ JCI Insight, 2023, 8(16)e170434] PubMed: 37606043
Cry1Δ11 mutation induces ADHD-like symptoms through hyperactive dopamine D1 receptor signaling [ JCI Insight, 2023, 8(16)e170434] PubMed: 37606043

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.