SBC-115076

Catalog No.S7976 Batch:S797602

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Technical Data

Formula

C31H33N3O5
Molecular Weight 527.61 CAS No. 489415-96-5
Solubility (25°C)* In vitro DMSO 33 mg/mL (62.54 mM)
Water Insoluble
Ethanol Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5% DMSO 95% Corn oil
0.4mg/ml Taking the 1 mL working solution as an example, add 50 μL of 8 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
2.5mg/ml Taking the 1 mL working solution as an example, add 50 μL of 50 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description SBC-115076 is a potent extracellular proprotein convertase subtilisin kexin type 9 (PCSK9) antagonist.
Targets
PCSK9 [1]
In vitro

In HepG2 cells, SBC-115076 increases the uptake of Fluorescent Dil-LDL. [1]
In vivo

In mice that are fed high fat diet, SBC-115076 (8 mg/kg) lowers cholesterol levels by 32%. [1]

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    THP-1 cells

  • Concentrations

    20 μM

  • Incubation Time

    24 h

  • Method

    Cells were treated with indicated concentration of drug for 24 h.

Selleck's SBC-115076 has been cited by 8 publications

Fumarate Hydratase Enhances the Therapeutic Effect of PD-1 Antibody in Colorectal Cancer by Regulating PCSK9 [ Cancers (Basel), 2024, 16(4)713] PubMed: 38398104
PCSK9i promoting the transformation of AS plaques into a stable plaque by targeting the miR-186-5p/Wipf2 and miR-375-3p/Pdk1/Yap1 in ApoE-/- mice [ Front Med (Lausanne), 2024, 11:1284199] PubMed: 38596793
PCSK9 inhibitor effectively alleviated cognitive dysfunction in a type 2 diabetes mellitus rat model [ PeerJ, 2024, 12:e17676] PubMed: 39157774
Role of PCSK9 in Homocysteine-Accelerated Lipid Accumulation in Macrophages and Atherosclerosis in ApoE-/- Mice [ Front Cardiovasc Med, 2021, 8:746989] PubMed: 34660746
A proprotein convertase subtilisin/kexin type 9 inhibitor provides comparable efficacy with lower detriment than statins on mitochondria of oxidative muscle of obese estrogen-deprived rats [ Menopause, 2020, 27(10):1155-1166] PubMed: 32576799
Effect of aerobic exercise on blood lipid of hyperlipidemia rats and its mechanism [ Journal of Second Military Medical University, 2019, 40(4): 412-419] PubMed: None
A New Strategy for Rapidly Screening Natural Inhibitors Targeting the PCSK9/LDLR Interaction In Vitro. [ Molecules, 2018, 23(9)] PubMed: 30235833
Ruxolitinib and Polycation Combination Treatment Overcomes Multiple Mechanisms of Resistance of Pancreatic Cancer Cells to Oncolytic Vesicular Stomatitis Virus [ J Virol, 2017, 91(16)e00461-17] PubMed: 28566376

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.