SB-334867

Catalog No.S7585 Batch:S758501

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Technical Data

Formula

C17H13N5O2
Molecular Weight 319.32 CAS No. 792173-99-0
Solubility (25°C)* In vitro DMSO 63 mg/mL (197.29 mM)
Ethanol 3 mg/mL (9.39 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description SB-334867 is a selective orexin-1 (OX1) receptor antagonist.
Targets
OX1 receptor [1]
In vitro In CHO-OX1 cells, SB-334867 inhibits the orexin-A (10 nM) and orexin-B (100 nM)-induced calcium responses with pKB of 7.27 and 7.23 respectively, without effect on the UTP (3 microM)-induced calcium response. [1]
In vivo In both male and female rats, SB-334867 (30 mg/kg, i.p.) significantly reduces natural and orexin-A-induced food intake. [2] SB-334867 (2 mg/kg, i.v.) blocks the effects of antipsychotic drugs on dopamine neuronal activity in rats. [3] SB-334867 also inhibits the development of morphine analgesic tolerance in rats. [4]

Protocol (from reference)

Animal Study:[2]
  • Animal Models

    Male and female Sprague–Dawley rats

  • Dosages

    30 mg/kg

  • Administration

    i.p.

Selleck's SB-334867 has been cited by 2 publications

Orexin A alleviates neuroinflammation via OXR2/CaMKKβ/AMPK signaling pathway after ICH in mice [ J Neuroinflammation, 2020, 17(1):187] PubMed: 32539736
Effects of Sleep Deprivation (SD) on Rats via ERK1/2 Signaling Pathway. [ Med Sci Monit, 2019, 25:2886-2895] PubMed: 31002658

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.