SAR407899 hydrochloride

Catalog No.E2385 Batch:E238501

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Technical Data

Formula

C14H16N2O2.ClH

Molecular Weight 280.75 CAS No. 923262-96-8
Solubility (25°C)* In vitro Water 56 mg/mL (199.46 mM)
DMSO 28 mg/mL (99.73 mM)
Ethanol 1 mg/mL (3.56 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description SAR407899 hydrochloride is a selective, potent and ATP-competitive Rho kinase (ROCK) inhibitor, with an IC50 of 135 nM for ROCK-2, and Ki values of 36 and 41 nM for human and rat ROCK-2, respectively.
Targets
human ROCK-2 [1]
(in assay of ROCK enzymatic activity)
rat ROCK-2 [1]
(in assay of ROCK enzymatic activity)
ROCK-2 [1]
(in selectivity assays)
36 nM(Ki) 41 nM(Ki) 135 nM(Ki)

Protocol (from reference)

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.