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Technical Data
| Formula | C18H15Cl4N3OS |
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| Molecular Weight | 463.21 | CAS No. | 1164470-53-4 | |
| Solubility (25°C)* | In vitro | DMSO | 93 mg/mL (200.77 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor. | |
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| Targets |
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| In vitro | Sal003 increases eIF2α phosphorylation status by blocking eIF2a phosphatases in cells. [1] In mouse embryonic fibroblasts (MEFs), Sal003 causes dissociation of polysomes by increasing eIF2a phosphorylation. Sal003 impairs late-long-term potentiation (L-LTP) in an ATF4-dependent mode in hippocampal slices from WT mice. [2] In addition, eIF2α phosphorylation by Sal003 also enhances apoptotic signaling induced by subtilase cytotoxin (SubAB). [3] | |
| In vivo | Sal003 impairs spatial long-term memory formation in rats. [2] |
Protocol (from reference)
| Animal Study:[2] |
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References
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Selleck's Sal003 has been cited by 4 publications
| Sal003 alleviated intervertebral disc degeneration by inhibiting apoptosis and extracellular matrix degradation through suppressing endoplasmic reticulum stress pathway in rats [ Front Pharmacol, 2023, 14:1095307] | PubMed: 36744257 |
| Regulation of RNA methylation by therapy treatment, promotes tumor survival [ bioRxiv, 2023, 2023.05.19.540602] | PubMed: 37292633 |
| Regulation of RNA methylation by therapy treatment, promotes tumor survival [ bioRxiv, 2023, 2023.05.19.540602] | PubMed: 37292633 |
| Regulation of RNA methylation by therapy treatment, promotes tumor survival [ bioRxiv, 2023, 2023.05.19.540602] | PubMed: 37292633 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.