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Formula | C12H15N5O3 |
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Molecular Weight | 277.28 | CAS No. | 142217-69-4 | ||||||||
Solubility (25°C)* | In vitro | DMSO | 55 mg/mL (198.35 mM) | ||||||||
Water | Insoluble | ||||||||||
Ethanol | Insoluble | ||||||||||
In vivo (Add solvents to the product individually and in order) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Entecavir(BMS200475,SQ34676), a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV). |
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In vitro | For treatment of hepatitis B virus, combinations of ETV with each of the other HBV NRTI antivirals, adefovir, tenofovir, and lamivudine at 10 times their respective Cmax levels fails to result in cellular or mitochondrial toxicity, and displays no DNA polymerase gamma inhibition.[1] |
In vivo | Treatment with Entecavir in combination with AIC649, Induces tightly regulated Immunological and virological responses during active and maintenance ereatment in the woodchuck model of chronic hepatitis B. |
Cell Assay: |
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Significance of hepatitis B virus capsid dephosphorylation via polymerase [ J Biomed Sci, 2024, 31(1):34] | PubMed: 38561844 |
A therapeutic hepatitis B mRNA vaccine with strong immunogenicity and persistent virological suppression [ NPJ Vaccines, 2024, 9(1):22] | PubMed: 38310094 |
Preclinical and clinical antiviral characterization of AB-836, a potent capsid assembly modulator against hepatitis B virus [ Antiviral Res, 2024, 231:106010] | PubMed: 39326502 |
Preclinical Antiviral and Safety Profiling of the HBV RNA Destabilizer AB-161 [ Viruses, 2024, 16(3)323] | PubMed: 38543689 |
Reverse Transcriptase Inhibition Disrupts Repeat Element Life Cycle in Colorectal Cancer [ Cancer Discov, 2022, candisc.1117.2021] | PubMed: 35320348 |
In vitro investigation of HBV clinical isolates from Chinese patients reveals that genotype C isolates possess higher infectivity than genotype B isolates [ Virol Sin, 2022, S1995-820X(22)00062-1] | PubMed: 35314401 |
Rapamycin inhibits hepatitis B virus covalently closed circular DNA transcription by enhancing the ubiquitination of HBx [ Front Microbiol, 2022, 13:850087] | PubMed: 36033851 |
Genotoxicity assessment of potentially mutagenic nucleoside analogues using ToxTracker® [ Toxicol Lett, 2022, 362:50-58] | PubMed: 35569722 |
Preclinical characterization of AB-506, an inhibitor of HBV replication targeting the viral core protein [ Antiviral Res, 2021, 197:105211] | PubMed: 34826506 |
A cell-based assay to discover inhibitors of SARS-CoV-2 RNA dependent RNA polymerase [ Antiviral Res, 2021, S0166-3542(21)00068-1] | PubMed: 33894278 |
RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.