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Technical Data
| Formula | C6H11NO2S |
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| Molecular Weight | 161.22 | CAS No. | 21593-77-1 | |
| Solubility (25°C)* | In vitro | Water | 32 mg/mL (198.48 mM) | |
| DMSO | 4 mg/mL (24.81 mM) | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | S-Allyl cysteine (SAC, S-Allylcysteine), a natural constituent of fresh garlic, has antioxidant and anticancer properties in animals. S-Allyl cysteine has an anticancer effect through the induction of apoptosis and a cell cycle arrest. |
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| In vitro | S-Allyl cysteine (SAC) could suppress NF-κB activation and lower nitric oxide (NO) production in interferon-γ-stimulated RAW264.7 cells[2]. SAC is known for its anti-apoptotic and antioxidant effects in a range of types of somatic cells. SAC manifests antioxidant properties for example in the nervous and cardiovascular systems[3]. |
| In vivo | SAC significantly prevents NSAID-induced gastric ulceration by blocking inflammation[1]. The dietary intake of SAC suppresses protein expression of NF-κB, MAPK, and PKC in kidney of diabetic mice, which in turn declines renal activity and mRNA expression of NOS and COX-2, finally lowers the formation of ROS, nitric oxide, IL-6, TNF-α, and PGE2, as well as improves renal functions. Therefore, SAC is potent anti-inflammatory agents against diabetic nephropathy[2]. |
Protocol (from reference)
| Cell Assay:[3] |
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| Animal Study:[1] |
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References
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RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.