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Technical Data
| Formula | C23H22O6 |
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| Molecular Weight | 394.42 | CAS No. | 83-79-4 | |
| Solubility (25°C)* | In vitro | DMSO | 79 mg/mL (200.29 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Rotenone is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone inhibits NADH/DB oxidoreductase and NADH oxidase with IC50 of 28.8 nM and 5.1 nM, respectively. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. |
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| In vitro | Rotenone inhibits NADH/DB oxidoreductase and NADH oxidase, and induces apoptosis through enhancing mitochondrial reactive oxygen species production.[1] |
| In vivo | Rotenone, a mitochondrial toxin, induce the up-regulation of alpha-synuclein (alpha-syn) in PD models.[2] |
Protocol (from reference)
| Cell Assay: |
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References
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Selleck's Rotenone has been cited by 27 publications
| Tumor mitochondrial oxidative phosphorylation stimulated by the nuclear receptor RORγ represents an effective therapeutic opportunity in osteosarcoma [ Cell Rep Med, 2024, 5(5):101519] | PubMed: 38692271 |
| SPTBN2 suppresses ferroptosis in NSCLC cells by facilitating SLC7A11 membrane trafficking and localization [ Redox Biol, 2024, 70:103039] | PubMed: 38241838 |
| Novel therapeutic strategies targeting bypass pathways and mitochondrial dysfunction to combat resistance to RET inhibitors in NSCLC [ Biochim Biophys Acta Mol Basis Dis, 2024, 1870(6):167249] | PubMed: 38768929 |
| Identifying the potential genes in alpha synuclein driving ferroptosis of Parkinson's disease [ Sci Rep, 2023, 13(1):16893] | PubMed: 37803093 |
| Ginsenoside Rg1 ameliorates chronic intermittent hypoxia-induced vascular endothelial dysfunction by suppressing the formation of mitochondrial reactive oxygen species through the calpain-1 pathway [ J Ginseng Res, 2023, 47(1):144-154] | PubMed: 36644390 |
| Copper induces cell death by targeting lipoylated TCA cycle proteins [ Science, 2022, 375(6586):1254-1261] | PubMed: 35298263 |
| Novel roles of RTN4 and CLIMP-63 in regulating mitochondrial structure, bioenergetics and apoptosis [ Cell Death Dis, 2022, 13(5):436] | PubMed: 35508606 |
| Themis is indispensable for IL-2 and IL-15 signaling in T cells [ Sci Signal, 2022, 15(721):eabi9983] | PubMed: 35167340 |
| Reduction of ROS-HIF1α-driven glycolysis by taurine alleviates Streptococcus uberis infection [ Food Funct, 2022, 10.1039/d1fo03909a] | PubMed: 35112684 |
| Spautin-1 inhibits mitochondrial complex I and leads to suppression of the unfolded protein response and cell survival during glucose starvation [ Sci Rep, 2022, 12(1):11533] | PubMed: 35798783 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.