Ro5-3335

Catalog No.E1245 Batch:E124501

Technical Data

Formula

C₁₃H₁₀ClN₃O

Molecular Weight

259.69

CAS No.

30195-30-3

Solubility (25°C)*

In vitro

DMSO

52 mg/mL (200.23 mM)

Water

Insoluble

Ethanol

Insoluble

In vivo (Add solvents to the product individually and in order)

Clear solution

1% DMSO 1 40% PEG 300 2 5%Tween80 3 54%ddH2O

0.5mg/ml

Taking the 1 mL working solution as an example, add 10 μL of 50 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 540 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description	Ro5-3335 is an inhibitor of Core binding factor leukemia (CBF leukemia), by interacting with RUNX1 and CBFβ directly, repressing RUNX1/CBFB-dependent transactivation and runx1-dependent hematopoiesis.

Protocol (from reference)

References

[1] Cunningham L, et al. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14592-7.

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.