RIN1 (RBPJ Inhibitor-1)

Catalog No.S3376 Batch:S337603

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Technical Data

Formula

C17H14FN3O2
Molecular Weight 311.31 CAS No. 2682114-39-0
Solubility (25°C)* In vitro DMSO 62 mg/mL (199.15 mM)
Ethanol 62 mg/mL (199.15 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description RIN1 (RBPJ Inhibitor-1) is a potent inhibitor of the transcription factor RBPJ that disrupts the interaction between NOTCH and RBPJ.
Targets
RBPJ [1]
In vitro

RBPJ Inhibitor-1 (RIN1) blocks the functional interaction of RBPJ with SHARP, a scaffold protein that forms a transcriptional repressor complex with RBPJ in the absence of NOTCH signaling. Consistent with disruption of NOTCH signaling, RIN1 inhibits the proliferation of hematologic cancer cell lines and promotes skeletal muscle differentiation from C2C12 myoblasts.[1]
In vivo

RBPJ Inhibitor-1 (RIN1) is a potent inhibitor of the transcription factor RBPJ that disrupts the interaction between NOTCH and RBPJ.

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    AD-293 cells

  • Concentrations

    2 µM

  • Incubation Time

    17 h

  • Method

    AD-293 cells were transfected with RBPJ-VP16myc and 48 hours later were treated±RIN1 (2 µM), Cycloheximide (CHX, 10 µg/ml) for an additional 17 hours and then assayed for Hes1-Luciferase activity.

Selleck's RIN1 (RBPJ Inhibitor-1) has been cited by 3 publications

Endothelial γ-protocadherins inhibit KLF2 and KLF4 to promote atherosclerosis [ Nat Cardiovasc Res, 2024, 3(9):1035-1048] PubMed: 39232138
Evaluation of the anticancer activity of RIN-1, a Notch signaling modulator, in head and neck squamous cell carcinoma [ Sci Rep, 2023, 13(1):13700] PubMed: 37607974
Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells [ Dev Cell, 2022, 57(2):260-276.e9] PubMed: 35077680

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.