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Technical Data
| Formula | C17H34N4O10.H2SO4 |
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| Molecular Weight | 552.55 | CAS No. | 53797-35-6 | |
| Solubility (25°C)* | In vitro | Water | 100 mg/mL (180.97 mM) | |
| DMSO | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Ribostamycin Sulfate(Vistamycin Sulfate,Landamycine) is an aminoglycoside antibiotic, containing a neutral sugar moiety, and is produced by Streptomyces ribosidificus. |
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| In vitro | Ribostamycin inhibits the chaperone activity of protein disulfide isomerase (PDI), but it does not inhibit the isomerase activity, a 100:1 molar ratio of ribostamycin to PDI is almost sufficient to completely inhibit the chaperone activity of PDI. Ribostamycin binds to purified bovine PDI with KD of 0.319 mM. Ribostamycin is especially effective against the gentamicin-resistant bacterium Klebsiella pneumoniae, which possesses aminoglycoside-modifying enzymes. [1] Ribostamycin exhibits antimicrobial activity against B. burgdorferi isolates with MIC of 18.7 mg/L. [2] Ribostamycin (16 mcg/mL) inhibits 100% of the P. stagnora strains and 95% of the P. wickerhamii strains, while Ribostamycin (16 mcg/mL) inhibits 100% of the P. zopfii strains. [3] |
| In vivo | Ribostamycin (400 mg/kg/day) shows the weakest ototoxicity against the cochlea and vestibular organs in guinea pigs. Ribostamycin (400 mg/kg/day), causing the weakest ototoxicity, shows a low drug concentration in the inner ear fluid of of guinea pigs. [4] |
Protocol (from reference)
References
Selleck's Ribostamycin Sulfate has been cited by 2 publications
| Identification of amitriptyline HCl, flavin adenine dinucleotide, azacitidine and calcitriol as repurposing drugs for influenza A H5N1 virus-induced lung injury. [ PLoS Pathog, 2020, 16;16(3):e1008341] | PubMed: 32176725 |
| Targeting the nsp2 Cysteine Protease of Chikungunya Virus Using FDA Approved Library and Selected Cysteine Protease Inhibitors. [ Pathogens, 2019, 8(3)] | PubMed: 31443266 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.