Relacorilant (CORT125134)

Catalog No.E1091 Batch:E109101

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Technical Data

Formula

C27H22F4N6O3S

Molecular Weight 586.56 CAS No. 1496510-51-0
Solubility (25°C)* In vitro DMSO 100 mg/mL (170.48 mM)
Ethanol 100 mg/mL (170.48 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Relacorilant (CORT125134) is a potent, selective and orally bioavailable glucocorticoid receptor antagonist, with a Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively.
Targets
glucocorticoid receptor [1]
(in HepG2 TAT assay)
Rat glucocorticoid receptor [1]
(in cell-based assay)
Human glucocorticoid receptor [1]
(in cell-based assay)
Monkey glucocorticoid receptor [1]
(in cell-based assay)
7.2 nM(Ki) 12 nM(Ki) 81.2 nM(Ki) 210 nM(Ki)

Protocol (from reference)

Selleck's Relacorilant (CORT125134) has been cited by 2 publications

Polypharmacological profiling across protein target families and cellular pathways using the multiplexed cell-based assay platform safetyProfiler reveals efficacy, potency and side effects of drugs [ Biomed Pharmacother, 2024, 180:117523] PubMed: 39405910
Circulating myomiRNAs as biomarkers in patients with Cushing's syndrome [ J Endocrinol Invest, 2023, 10.1007/s40618-023-02184-3] PubMed: 37682493

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.