Raphin1

Catalog No.S0528 Batch:S052802

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Technical Data

Formula

C8H8Cl2N4
Molecular Weight 231.08 CAS No. 2022961-17-5
Solubility (25°C)* In vitro DMSO 46 mg/mL (199.06 mM)
Ethanol 3 mg/mL (12.98 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5% DMSO 95% Corn oil
0.76mg/ml Taking the 1 mL working solution as an example, add 50 μL of 15.2 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
2.3mg/ml Taking the 1 mL working solution as an example, add 50 μL of 46 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Raphin1 is an orally bioavailable, selective inhibitor of R15B (PPP1R15B, a regulatory subunit of protein phosphatase 1). Raphin1 binds strongly to the R15B-PP1c holophosphatase with Kd of 33 nM.
Targets
R15B-PP1c [1]
(Cell-free assay)
33 nM(Kd)

Protocol (from reference)

Selleck's Raphin1 has been cited by 2 publications

GCN2 is a determinant of the response to WEE1 kinase inhibition in small-cell lung cancer [ Cell Rep, 2024, 43(8):114606] PubMed: 39120974
Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis [ Cell Stem Cell, 2022, 29(7):1119-1134.e7] PubMed: 35803229

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.